Anderson E
Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, MA 02115.
Am J Obstet Gynecol. 1989 Apr;160(4):782-8. doi: 10.1016/0002-9378(89)90292-5.
In this communication attention is called to some features of ovarian cyst formation in rats after exposure to 6 mg/100 gm body weight of dehydroepiandrosterone for 21 days. Cysts were identified by the transformation of mural granulosa cells into epithelial cells. The invaginations of the basal plasma membrane of the epithelial cells of the cyst are thought to be indications of the cells' involvement in active endocytosis. This endocytosis may be one strategy for moving fluid into the cyst. The filamentous actin of granulosa cells cultured in the presence of 10(-5) mol/L dehydroepiandrosterone was found to be deficient when compared with that of controls. This lack of filamentous actin coupled with other organelle degeneration is believed to lead to early atresia of granulosa cells in vitro in the presence of high concentrations of androgens.
在本交流中，我们关注了大鼠在以6毫克/100克体重的脱氢表雄酮处理21天后卵巢囊肿形成的一些特征。囊肿通过壁层颗粒细胞向上皮细胞的转化得以识别。囊肿上皮细胞基底质膜的内陷被认为是细胞参与活跃内吞作用的迹象。这种内吞作用可能是将液体移入囊肿的一种策略。与对照组相比，发现在10^(-5)摩尔/升脱氢表雄酮存在下培养的颗粒细胞的丝状肌动蛋白缺乏。这种丝状肌动蛋白的缺乏与其他细胞器变性相结合，被认为会导致在高浓度雄激素存在下体外颗粒细胞的早期闭锁。
