组织再生与病理学交叉点上的周细胞。
Pericytes at the intersection between tissue regeneration and pathology.
作者信息
Birbrair Alexander, Zhang Tan, Wang Zhong-Min, Messi Maria Laura, Mintz Akiva, Delbono Osvaldo
机构信息
*Department of Internal Medicine-Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina, Medical Center Boulevard, Winston Salem, NC 27157, U.S.A.
‡Department of Neurosurgery, Wake Forest School of Medicine, Winston-Salem, North Carolina, Medical Center Boulevard, Winston Salem, NC 27157, U.S.A.
出版信息
Clin Sci (Lond). 2015 Jan;128(2):81-93. doi: 10.1042/CS20140278.
Abstract
Perivascular multipotent cells, pericytes, contribute to the generation and repair of various tissues in response to injury. They are heterogeneous in their morphology, distribution, origin and markers, and elucidating their molecular and cellular differences may inform novel treatments for disorders in which tissue regeneration is either impaired or excessive. Moreover, these discoveries offer novel cellular targets for therapeutic approaches to many diseases. This review discusses recent studies that support the concept that pericyte subtypes play a distinctive role in myogenesis, neurogenesis, adipogenesis, fibrogenesis and angiogenesis.
摘要
血管周围多能细胞，即周细胞，在损伤时有助于各种组织的生成和修复。它们在形态、分布、起源和标志物方面具有异质性，阐明它们的分子和细胞差异可能为组织再生受损或过度的疾病提供新的治疗方法。此外，这些发现为许多疾病的治疗方法提供了新的细胞靶点。本综述讨论了最近的研究，这些研究支持周细胞亚型在肌生成、神经发生、脂肪生成、纤维生成和血管生成中发挥独特作用的概念。
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本文引用的文献
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Type-2 pericytes participate in normal and tumoral angiogenesis.2 型周细胞参与正常和肿瘤血管生成。
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In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model.脑损伤和阿尔茨海默病模型中反应性神经胶质细胞在体直接重编程为功能性神经元。
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