Al-Saab Raghad, Haddad Shaden
Department of Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Damascus, Syria.
Int J Endocrinol Metab. 2014 Jul 1;12(3):e17954. doi: 10.5812/ijem.17954. eCollection 2014 Jul.
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women in reproductive age. In many cases, PCOS is associated with infertility and increased risk of miscarriage. Recent studies have detected the presence of several organ specific and nonspecific autoantibodies in women with PCOS.
The aim of this study was to evaluate the prevalence and levels of thyroid antibodies in euthyroid women with PCOS in Syria.
This study included 56 euthyroid women with PCOS and 30 healthy women as a control group. PCOS was defined according to the revised 2003 Rotterdam criteria. Thyroid function was evaluated by measurement of serum TSH and FT4 levels. Antithyroid peroxidase and antithyroglobulin antibodies (anti-TPO and anti-TG, respectively) were detected as markers for thyroid autoimmunity. All parameters were measured using electrochemiluminescence immunoassay.
Women with PCOS had higher serum levels of anti-TPO in comparison to controls (39.9 ± 59.5 and 18.9 ± 11.2 IU/mL, respectively; P < 0.05) and no significant difference was found in serum levels of anti-TG, TSH, or FT4 between the two groups. Patients with PCOS had a higher prevalence of positive results for anti-TG and/or anti-TPO in comparison to controls (28.6% and 3.3%, respectively; P<0.05), anti-TPO alone (19.6% and 3.3%, respectively; P < 0.05) and anti-TG alone (21.4% and 3.3%, respectively; P < 0.05). No significant associations were found between antibodies and studied hormones.
High prevalence of thyroid antibodies in euthyroid patients with PCOS refers to the importance of investigation for thyroid autoimmune state in those patients.
多囊卵巢综合征（PCOS）是育龄期女性最常见的内分泌疾病之一。在许多情况下，PCOS与不孕和流产风险增加有关。最近的研究在PCOS女性中检测到几种器官特异性和非特异性自身抗体的存在。
本研究的目的是评估叙利亚甲状腺功能正常的PCOS女性中甲状腺抗体的患病率和水平。
本研究纳入56例甲状腺功能正常的PCOS女性和30例健康女性作为对照组。PCOS根据2003年修订的鹿特丹标准定义。通过测量血清促甲状腺激素（TSH）和游离甲状腺素（FT4）水平评估甲状腺功能。检测抗甲状腺过氧化物酶和抗甲状腺球蛋白抗体（分别为抗TPO和抗TG）作为甲状腺自身免疫的标志物。所有参数均采用电化学发光免疫分析法测量。
与对照组相比，PCOS女性的血清抗TPO水平更高（分别为39.9±59.5和18.9±11.2 IU/mL；P<0.05），两组之间抗TG、TSH或FT4的血清水平无显著差异。与对照组相比，PCOS患者抗TG和/或抗TPO阳性结果的患病率更高（分别为28.6%和3.3%；P<0.05），单独抗TPO（分别为19.6%和3.3%；P<0.05）和单独抗TG（分别为21.4%和3.3%；P<0.05）。未发现抗体与所研究激素之间存在显著关联。
甲状腺功能正常的PCOS患者中甲状腺抗体的高患病率表明对这些患者进行甲状腺自身免疫状态调查的重要性。
