通过TDAE策略合成含环氧乙烷环的新型喹喔啉及其在神经母细胞瘤细胞系中的体外评价
Synthesis of new quinoxalines containing an oxirane ring by the TDAE strategy and in vitro evaluation in neuroblastoma cell lines.
作者信息
Montana Marc, Correard Florian, Khoumeri Omar, Esteve Marie-Anne, Terme Thierry, Vanelle Patrice
机构信息
Aix-Marseille Université, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, Marseille 13385, France.
Aix-Marseille Université, INSERM, CRO2, UMR_S911, Marseille 13385, France.
出版信息
Molecules. 2014 Sep 18;19(9):14987-98. doi: 10.3390/molecules190914987.
Neuroblastoma is an aggressive pediatric malignancy with significant chemotherapeutic resistance. In order to obtain new compounds active on neuroblastoma cell lines, we investigated the reactivity of carbanion formed via TDAE in quinoxaline series. The new synthesized compounds were tested for their anti-proliferative activity on two neuroblastoma cell lines, and seven oxirane derivatives obtained interesting activities.
神经母细胞瘤是一种侵袭性儿科恶性肿瘤，具有显著的化疗耐药性。为了获得对神经母细胞瘤细胞系有活性的新化合物，我们研究了通过四氰基乙烯（TDAE）在喹喔啉系列中形成的碳负离子的反应性。对新合成的化合物在两种神经母细胞瘤细胞系上进行了抗增殖活性测试，七种环氧乙烷衍生物获得了有趣的活性。
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