von Mühlendahl K E, Brämswig J, Traupe H, Happle R
Kinderhospital Osnabrück, Universitäts-Kinderklinik.
Dtsch Med Wochenschr. 1989 May 5;114(18):712-4. doi: 10.1055/s-2008-1066661.
In three boys, aged 12.5, 14 and 16 years, respectively, acne of the fulminans type developed after eight to twelve months' administration of 250 mg testosterone weekly or 500 mg every second week. Numerous deep and painful pustules grew, dominantly on the chest and back, in one of the boys also in the face. In addition fever and fatiguability set in, as well as bone and joint pains in some. Erythrocyte sedimentation rate and leukocyte counts were raised. Testosterone was at once discontinued and isotretinoin, in one boy also antibiotics, administered, this treatment lasting for 8 to 13 months. All three boys were left with disfiguring scars. Before testosterone is given to arrest growth in tall boys both patient and parents should be told of these potentially severe side effects.
分别在3名年龄为12.5岁、14岁和16岁的男孩中，在每周服用250毫克睾酮或每两周服用500毫克睾酮8至12个月后，出现了暴发性痤疮。长出了许多深部且疼痛的脓疱，主要分布在胸部和背部，其中一名男孩的面部也有。此外，还出现了发热、疲劳，部分人还伴有骨痛和关节痛。红细胞沉降率和白细胞计数升高。睾酮立即停用，并给予异维A酸治疗，其中一名男孩还使用了抗生素，治疗持续了8至13个月。所有三名男孩都留下了毁容性疤痕。在给高个子男孩使用睾酮来阻止生长之前，应告知患者及其父母这些潜在的严重副作用。
