Naito M, Hayashi T, Kuzuya M, Funaki C, Asai K, Kuzuya F
Department of Geriatrics, Nagoya University School of Medicine, Japan.
FEBS Lett. 1989 Apr 24;247(2):358-60. doi: 10.1016/0014-5793(89)81370-5.
We studied the effect of fibrinogen on the migration of bovine aortic smooth muscle cells in culture, using a Neuro Probe 48-well micro chemotaxis chamber. Fibrinogen stimulated the migration of the cells dose-dependently at concentrations from 30 to 1000 micrograms/ml. A modified checkerboard analysis of the response demonstrated that the effect was largely chemotactic in nature. The present results suggest that fibrinogen may play an important role in the pathogenesis of arterial intimal thickening and atherosclerosis.
我们使用Neuro Probe 48孔微量趋化性小室，研究了纤维蛋白原对培养的牛主动脉平滑肌细胞迁移的影响。纤维蛋白原在30至1000微克/毫升的浓度范围内，呈剂量依赖性地刺激细胞迁移。对该反应进行的改良棋盘分析表明，这种作用在很大程度上具有趋化性。目前的结果表明，纤维蛋白原可能在动脉内膜增厚和动脉粥样硬化的发病机制中起重要作用。
