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J Cell Biol. 1987 Nov;105(5):2037-41. doi: 10.1083/jcb.105.5.2037.
2
Cultured bovine aortic endothelial cells secrete factor(s) chemotactic for aortic smooth muscle cells.培养的牛主动脉内皮细胞分泌对主动脉平滑肌细胞有趋化作用的因子。
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Serotonin-stimulated aortic endothelial cells secrete a novel T lymphocyte chemotactic and growth factor.
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本文引用的文献

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The histogenesis of the arteries of the chick embryo.鸡胚动脉的组织发生
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An endothelial cell-derived growth factor.一种内皮细胞衍生生长因子。
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3
Minimization of variation in the response to different proteins of the Coomassie blue G dye-binding assay for protein.考马斯亮蓝G染料结合法测定蛋白质时，使对不同蛋白质的反应变化最小化。
Anal Biochem. 1981 Sep 1;116(1):53-64. doi: 10.1016/0003-2697(81)90321-3.
4
Cultured endothelial cells produce a heparinlike inhibitor of smooth muscle cell growth.培养的内皮细胞产生一种平滑肌细胞生长的类肝素抑制剂。
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Migration of cultured vascular cells in response to plasma and platelet-derived factors.
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6
Inhibition of vascular smooth muscle cell growth by endothelial cell-derived heparin. Possible role of a platelet endoglycosidase.内皮细胞源性肝素对血管平滑肌细胞生长的抑制作用。血小板内切糖苷酶的可能作用。
J Biol Chem. 1982 Oct 10;257(19):11256-60.
7
The origin of the glomerular endothelium.肾小球内皮的起源。
Cell Differ. 1982 Jan;11(1):35-9. doi: 10.1016/0045-6039(82)90014-8.
8
Platelet-derived growth factor in chemotactic for fibroblasts.血小板衍生生长因子对成纤维细胞具有趋化作用。
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9
Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor.平滑肌细胞与胶原蛋白的附着及其向血小板衍生生长因子的迁移。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3669-72. doi: 10.1073/pnas.78.6.3669.
10
Culture of retinal capillary cells using selective growth media.使用选择性生长培养基培养视网膜毛细血管细胞。
Microvasc Res. 1983 Jul;26(1):74-80. doi: 10.1016/0026-2862(83)90056-0.

内皮细胞在体外对血小板衍生生长因子样趋化因子的极化分泌

Polarized secretion of a platelet-derived growth factor-like chemotactic factor by endothelial cells in vitro.

作者信息

Zerwes H G, Risau W

机构信息

Max-Planck-Institut für Entwicklungsbiologie, Tübingen, Federal Republic of Germany.

出版信息

J Cell Biol. 1987 Nov;105(5):2037-41. doi: 10.1083/jcb.105.5.2037.

DOI:10.1083/jcb.105.5.2037
PMID:3680370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2114851/
Abstract

Cultured bovine aortic endothelial cells secrete a potent migration-stimulating factor for vascular smooth muscle cells (SMCs) and adventitial fibroblasts. Vascular pericytes are 20-fold less responsive, and endothelial cells themselves do not respond at all. Checkerboard analysis of SMC migration in a micro-chemotaxis chamber assay shows that the factor is chemotactic. Chemotactic activity for SMCs and adventitial fibroblasts is specifically inhibited by antibodies against platelet-derived growth factor. Endothelial cells cultured on nitrocellulose filters secrete the platelet-derived growth factor-like factor almost exclusively into the basal compartment. We suggest that this factor plays an important role in the recruitment of vascular wall cells during the morphogenesis of blood vessels and pathological conditions, such as atherosclerosis.

摘要

培养的牛主动脉内皮细胞分泌一种对血管平滑肌细胞（SMC）和外膜成纤维细胞有强大迁移刺激作用的因子。血管周细胞的反应性低20倍，而内皮细胞本身则完全没有反应。在微趋化室试验中对SMC迁移进行的棋盘分析表明，该因子具有趋化作用。针对血小板衍生生长因子的抗体可特异性抑制SMC和外膜成纤维细胞的趋化活性。在硝酸纤维素滤膜上培养的内皮细胞几乎只将血小板衍生生长因子样因子分泌到基底室。我们认为，该因子在血管形态发生和诸如动脉粥样硬化等病理状况期间血管壁细胞的募集过程中发挥重要作用。