Woman and Baby Division, Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, the Netherlands.
Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus Medical Center, Rotterdam, the Netherlands.
Fertil Steril. 2014 Nov;102(5):1444-1451.e3. doi: 10.1016/j.fertnstert.2014.08.001. Epub 2014 Sep 16.
To study the cardiometabolic profile characteristics and compare the prevalence of cardiovascular (CV) risk factors between women with different polycystic ovary syndrome (PCOS) phenotypes.
A cross-sectional multicenter study analyzing 2,288 well phenotyped women with PCOS.
Specialized reproductive outpatient clinic.
PATIENT(S): Women of reproductive age (18-45 years) diagnosed with PCOS.
INTERVENTION(S): Women suspected of oligo- or anovulation underwent a standardized screening consisting of a systematic medical and reproductive history taking, anthropometric measurements, and transvaginal ultrasonography followed by an extensive endocrinologic/metabolic evaluation.
MAIN OUTCOME MEASURE(S): Differences in cardiometabolic profile characteristics and CV risk factor prevalence between women with different PCOS phenotypes, i.e., obesity/overweight, hypertension, insulin resistance, dyslipidemia, and metabolic syndrome.
RESULT(S): Women with hyperandrogenic PCOS (n=1,219; 53.3% of total) presented with a worse cardiometabolic profile and a higher prevalence of CV risk factors, such as obesity and overweight, insulin resistance, and metabolic syndrome, compared with women with nonhyperandrogenic PCOS. In women with nonhyperandrogenic PCOS overweight/obesity (28.5%) and dyslipidemia (low-density lipoprotein cholesterol≥3.0 mmol/L; 52.2%) were highly prevalent.
CONCLUSION(S): Women with hyperandrogenic PCOS have a worse cardiometabolic profile and higher prevalence of CV risk factors compared with women with nonhyperandrogenic PCOS. However, all women with PCOS should be screened for the presence of CV risk factors, since the frequently found derangements at a young age imply an elevated risk for the development of CV disease later in life.
研究不同多囊卵巢综合征（PCOS）表型女性的心脏代谢特征，并比较心血管（CV）危险因素的患病率。
一项横断面多中心研究，分析了 2288 名表型良好的 PCOS 女性。
专门的生殖门诊。
年龄在 18-45 岁之间被诊断为 PCOS 的育龄妇女。
疑似少排卵或无排卵的妇女接受了标准化筛查，包括系统的医学和生殖史采集、人体测量和经阴道超声检查，然后进行广泛的内分泌/代谢评估。
不同 PCOS 表型女性的心脏代谢特征和 CV 危险因素患病率的差异，即肥胖/超重、高血压、胰岛素抵抗、血脂异常和代谢综合征。
高雄激素 PCOS 女性（n=1219；占总数的 53.3%）的心脏代谢特征更差，CV 危险因素的患病率更高，如肥胖和超重、胰岛素抵抗和代谢综合征，与非高雄激素 PCOS 女性相比。非高雄激素 PCOS 女性中，超重/肥胖（28.5%）和血脂异常（低密度脂蛋白胆固醇≥3.0mmol/L；52.2%）的患病率很高。
与非高雄激素 PCOS 女性相比，高雄激素 PCOS 女性的心脏代谢特征更差，CV 危险因素的患病率更高。然而，所有 PCOS 女性都应筛查 CV 危险因素的存在，因为年轻时经常出现的异常意味着以后发生 CV 疾病的风险增加。
