Laurent V, de Vernejoul M C, Brouard A, Terrier J L, Miravet L, Kuntz D
Département de Pharmacie, Hôpital Lariboisière, Paris.
Presse Med. 1989 Apr 1;18(13):679-82.
In order to find out whether the response of osteoporosis to sodium fluoride treatment or complications arising from this treatment are related to the retention of fluoride in bones, we measured bone fluoride concentrations in 30 patients with primary osteoporosis who had been treated with sodium fluoride for 1 to 8 years. We found a significant correlation (r = 0.74, P less than 0.001) between bone fluoride concentration and total amount of fluoride ingested. However, with any given amount of sodium fluoride, the bone fluoride concentration could vary by up to three times from a patient to another. There was a significant correlation between bone fluoride concentration and trabecular bone volume on the hand (r = 0.54, P less than 0.001) and thickness of osteoid borders measured on the same biopsy specimen on the other hand (r = 0.45, P less than 0.001). Five patients developed lower limb bone fissures after 11 to 18 months of sodium fluoride treatment, but their bone fluoride concentration was not significantly different from that of the 25 patients who had no fracture. These data suggest a relationship between the degree of stimulation of bone formation by fluoride and the bone concentration of that substance; however, peripheral fractures are not dependent on bone fluoride concentration.
为了确定骨质疏松症对氟化钠治疗的反应或该治疗引起的并发症是否与骨骼中氟的潴留有关，我们测量了30例接受氟化钠治疗1至8年的原发性骨质疏松症患者的骨氟浓度。我们发现骨氟浓度与摄入的氟总量之间存在显著相关性（r = 0.74，P < 0.001）。然而，对于任何给定剂量的氟化钠，不同患者之间的骨氟浓度差异可达三倍之多。骨氟浓度与手部小梁骨体积之间存在显著相关性（r = 0.54，P < 0.001），另一方面，在同一活检标本上测量的类骨质边界厚度与之也存在显著相关性（r = 0.45，P < 0.001）。5例患者在接受氟化钠治疗11至18个月后出现下肢骨裂，但他们的骨氟浓度与25例未发生骨折的患者相比无显著差异。这些数据表明氟对骨形成的刺激程度与该物质在骨骼中的浓度之间存在关联；然而，周围骨折并不取决于骨氟浓度。
