骨质疏松症：氟诱导轴外骨形成的影像学检测

Osteoporosis: radiographic detection of fluoride-induced extra-axial bone formation.

作者信息

Schulz E E, Engstrom H, Sauser D D, Baylink D J

出版信息

Radiology. 1986 May;159(2):457-62. doi: 10.1148/radiology.159.2.3961177.

DOI:10.1148/radiology.159.2.3961177

Abstract

New bone formation in the peripheral skeleton was detected radiographically in 67% (22/33) of patients studied for new periarticular pain among 72 patients with osteoporosis being treated with fluoride, 66-88 mg/d, for 6 or more months. Changes included periosteal and endosteal new bone formation as well as trabecular thickening and were localized in areas of high mechanical stress. Sufficient mineral deposition for radiographic detection required 6 or more months of fluoride treatment. Radiologists must differentiate fluoride-induced new bone formation from other-processes, such as fractures and tumor, and elicit information on fluoride intake in suspicious cases.

摘要

在72例接受氟化物治疗的骨质疏松症患者中，对其中33例因新出现的关节周围疼痛而接受研究的患者进行X线检查，发现67%（22/33）的患者外周骨骼有新骨形成。这些患者每天服用66 - 88毫克氟化物，疗程达6个月或更长时间。X线变化包括骨膜和骨内膜新骨形成以及小梁增粗，且这些变化局限于机械应力较高的区域。X线检测所需的足够矿物质沉积需要6个月或更长时间的氟化物治疗。放射科医生必须将氟化物诱导的新骨形成与其他病变（如骨折和肿瘤）区分开来，并在可疑病例中了解氟化物摄入情况。