Chang Bin, Wada Akihito, Hosoya Mitsuaki, Oishi Tomohiro, Ishiwada Naruhiko, Oda Megumi, Sato Tetsuya, Terauchi Yoshihiko, Okada Kenji, Nishi Junichiro, Akeda Hideki, Kamiya Hitoshi, Ohnishi Makoto, Ihara Toshiaki
Department of Bacteriology I, National Institute of Infectious Diseases.
Jpn J Infect Dis. 2014;67(5):356-60. doi: 10.7883/yoken.67.356.
Group B Streptococcus (GBS) is one of the leading causes of neonatal bacterial infections. Population-based surveillance of GBS-related invasive diseases among newborns and infants from 10 prefectures in Japan was performed between 2007 and 2012. The characteristics of cases and isolated GBS are described in this study. The incidence rate of GBS-related invasive diseases was 0.13 per 1,000 live births. Analysis of GBS samples obtained from 60 invasive cases showed that the most frequent serotypes were III (48.3%), Ia (30.0%), and Ib (10.0%). All isolates were susceptible to penicillin G, ampicillin, cefotaxime, imipenem, and panipenem. However, 14, 2, and 7 isolates were resistant to erythromycin, clindamycin, and both erythromycin and clindamycin, respectively. Multilocus sequence typing revealed that GBS sequence type (ST) 23, ST17, and ST335 caused higher incidences of meningitis. These data show that serotypes III, Ia, and Ib together caused more than 80% of invasive infections in Japanese infants, and that GBS strains are still susceptible to β-lactam antibiotics.
B族链球菌（GBS）是新生儿细菌性感染的主要病因之一。2007年至2012年期间，对日本10个县的新生儿和婴儿中与GBS相关的侵袭性疾病进行了基于人群的监测。本研究描述了病例和分离出的GBS的特征。GBS相关侵袭性疾病的发病率为每1000例活产中有0.13例。对从60例侵袭性病例中获得的GBS样本进行分析显示，最常见的血清型为III型（48.3%）、Ia型（30.0%）和Ib型（10.0%）。所有分离株对青霉素G、氨苄西林、头孢噻肟、亚胺培南和美罗培南均敏感。然而，分别有14株、2株和7株分离株对红霉素、克林霉素以及红霉素和克林霉素均耐药。多位点序列分型显示，GBS序列类型（ST）23、ST17和ST335导致脑膜炎的发病率较高。这些数据表明，III型、Ia型和Ib型血清型共同导致了日本婴儿中超过80%的侵袭性感染，并且GBS菌株仍然对β-内酰胺类抗生素敏感。
