Stevenson R W, Steiner K E, Green D R, Cherrington A D
Biochim Biophys Acta. 1984 Aug 17;804(4):414-8. doi: 10.1016/0167-4889(84)90068-5.
The effects of somatostatin on epinephrine's ability to stimulate glucose output have been examined in hepatocytes isolated from dogs fasted overnight. Half-maximal stimulation of phosphorylase a activity and glucose output occurred at an epinephrine concentration of approx. 5 X 10(-9) M. Somatostatin at 10, 100 or 1000 ng/ml had no effect on the ability of a maximal (1 X 10(-7) M) and a submaximal (1 X 10(-8) M) dose of epinephrine to activate phosphorylase at 2 min, or to stimulate glucose output over 20 min. Since the doses of somatostatin used in the present study are up to 50-fold higher than the blood concentrations commonly found when somatostatin is used in vivo to inhibit pancreatic hormone secretion, it seems unlikely that use of somatostatin in this way would affect stimulation of hepatic glycogenolysis by epinephrine in vivo.
在从禁食过夜的狗身上分离出的肝细胞中，研究了生长抑素对肾上腺素刺激葡萄糖生成能力的影响。磷酸化酶a活性和葡萄糖生成的半数最大刺激在肾上腺素浓度约为5×10⁻⁹ M时出现。10、100或1000 ng/ml的生长抑素对最大剂量（1×10⁻⁷ M）和次最大剂量（1×10⁻⁸ M）的肾上腺素在2分钟时激活磷酸化酶或在20分钟内刺激葡萄糖生成的能力没有影响。由于本研究中使用的生长抑素剂量比体内使用生长抑素抑制胰腺激素分泌时常见的血药浓度高出多达50倍，因此以这种方式使用生长抑素似乎不太可能影响体内肾上腺素对肝糖原分解的刺激。
