Tirosh E, Taub Y, Scher A, Jaffe M, Hochberg Z
Hannah Khoushi Child Development Center, Haifa Medical Center Israel.
Am J Ment Retard. 1989 May;93(6):652-6.
The thyroid function of 44 subjects with Down syndrome who were between 2 and 51 years of age was assessed. Three patients (7%) had hypothyroidism, and in 2 of them high titers of antimicrosomal antibody were detected. Seven additional subjects (16%) had low-borderline thyroid function, 6 with elevated thyroid stimulating hormone. These 7 subjects constituted the cohort for an evaluation of the short-term benefits of thyroid hormone supplementation in the low-borderline thyroid functional state. A double-blind crossover drug placebo trial failed to document any cognitive, social, response time, or physical changes attributable to the 8- to 14-week drug treatment period compared to an untreated matched control group. Results provided no evidence for the efficacy of short-term thyroid hormone therapy for this population.
对44名年龄在2至51岁之间的唐氏综合征患者的甲状腺功能进行了评估。3名患者（7%）患有甲状腺功能减退症，其中2名检测到高滴度的抗微粒体抗体。另外7名受试者（16%）甲状腺功能处于低临界状态，6名促甲状腺激素升高。这7名受试者构成了评估甲状腺激素补充剂对低临界甲状腺功能状态短期益处的队列。一项双盲交叉药物安慰剂试验未能证明与未治疗的匹配对照组相比，8至14周的药物治疗期会导致任何认知、社交、反应时间或身体变化。结果没有提供证据表明短期甲状腺激素治疗对该人群有效。
