Feng Jinqiu, Zhou Zengtong, Shen Xuemin, Wang Yufeng, Shi Linjun, Wang Yijun, Hu Ye, Sun Hongying, Liu Wei
Department of Preventive Dentistry, Shanghai Stomatological Disease Center, Shanghai, China.
Department of Oral Mucosal Diseases, Shanghai Key Laboratory of Stomatology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Oral Pathol Med. 2015 Aug;44(7):490-4. doi: 10.1111/jop.12264. Epub 2014 Sep 22.
An epidemiological study on the oral mucosal lesions (OMLs) in general population from China was scarce. The objective of this study was to investigate the prevalence and distribution of OMLs in Shanghai, China and to evaluate their association with demographic factors and smoking/drinking habits based on a large scaled population on a wide spectrum.
In this population-based cross-sectional study, 11054 community-dwelling individuals (M/F: 5140/5914; age range, 1-96 years) were randomly selected and examined according to WHO criteria.
The prevalence of OMLs was 10.8% in this study. A total of 1192 (M/F: 543/649; mean age, 56.9 years) individuals were presented with different types of OMLs. The most common type of OMLs was fissured tongue (prevalence of 3.15%), followed by recurrent aphthae (1.48%), traumatic ulcer (1.13%), and angular cheilitis (0.86%). The two most common potentially malignant disorders were oral lichen planus (0.81%) and leukoplakia (0.22%). Regression analysis revealed that the elderly age, smoking, and alcohol intake were statistically significant risk factors of OMLs with emphasis on leukokeratosis, leukoplakia, and lichen planus.
The prevalence and distribution of OMLs were elucidated in an eastern area of China, and the importance of tobacco and alcohol in the pathogenesis of OMLs was evidenced. Our data have provided baseline information about epidemiologic aspects of OMLs that can be valuable in organized program targeting on oral health and hygiene.
中国普通人群口腔黏膜病变（OML）的流行病学研究较少。本研究的目的是调查中国上海OML的患病率和分布情况，并基于广泛的大规模人群评估其与人口统计学因素以及吸烟/饮酒习惯的关联。
在这项基于人群的横断面研究中，随机选取了11054名社区居民（男/女：5140/5914；年龄范围1 - 96岁），并根据世界卫生组织标准进行检查。
本研究中OML的患病率为10.8%。共有1192名个体（男/女：543/649；平均年龄56.9岁）出现了不同类型的OML。最常见的OML类型是裂纹舌（患病率为3.15%），其次是复发性阿弗他溃疡（1.48%）、创伤性溃疡（1.13%）和口角炎（0.86%）。两种最常见的潜在恶性疾病是口腔扁平苔藓（0.81%）和白斑（0.22%）。回归分析显示，老年、吸烟和饮酒是OML的统计学显著危险因素，尤其与角化病、白斑和扁平苔藓有关。
阐明了中国东部地区OML的患病率和分布情况，并证明了烟草和酒精在OML发病机制中的重要性。我们的数据提供了有关OML流行病学方面的基线信息，这对于针对口腔健康和卫生的有组织计划可能具有重要价值。
