口腔白斑病的全球患病率：一项 1996 年至 2022 年的系统评价和荟萃分析。
The global prevalence of oral leukoplakia: a systematic review and meta-analysis from 1996 to 2022.
机构信息
Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for DentalMaterials, Haidian District, No.22, Zhongguancun South Avenue, Beijing, 100081, People's Republic of China.
Xiamen Key Laboratory of Stomatological Disease Diagnosis and Treatment, Stomatological Hospital of Xiamen Medical College, Xiamen, China.
出版信息
BMC Oral Health. 2023 Sep 6;23(1):645. doi: 10.1186/s12903-023-03342-y.
BACKGROUND
Oral leukoplakia(OLK) is a common oral potentially malignant disorder. The global prevalence of solely OLK was published in 2003, while the prevalence varied among different studies. In recent years, large-scale summary and definition-related analyses obtain insufficient attention. This study aimed to perform a systematic review of prevalence studies of oral leukoplakia and assess predisposing factors of its occurrence.
METHODS
The search terms ("Oral leukoplakia" OR OLK OR leukoplakia) AND (prevalence OR incidence OR epidemiology) were searched in databases (Pubmed, Embase, Scopus, and Web of Science) for OLK studies published from January 1996 until December 2022. The estimated prevalence calculation and risk of bias analysis used STATA 16.0.
RESULTS
We obtained 69 studies, including 1,263,028 participants, from 28 countries, and 6 continents. The prevalence was 1.39%, varying from 0.12 to 33.33%. The overall pooled estimated prevalence of OLK was 2.23% for population-based studies, 1.36% for clinic-based population studies, and 9.10% for specific populations. The pooled prevalence in different continents ranged from 0.33 to 11.74% with a statistical difference in the population-based calculation. The estimated prevalence of OLK was higher in males than in females. Those who smoked and consumed alcohol had a higher prevalence than those who did not.
CONCLUSION
Combining data from 69 published studies, the prevalence of OLK was determined as 1.39% and the pooling estimated global prevalence was 3.41%. The prevalence was relatively consistent and stable across different continents and different definitions. A higher pooled estimated prevalence was found among males, those aged over 60 years old, smokers, and alcohol consumers. The results from the included studies in this systematic review revealed that the prevalence was relatively consistent and stable across various definitions and continents, which may help in developing global treatment and prevention strategies for oral leukoplakia.
背景
口腔白斑病（OLK）是一种常见的口腔潜在恶性疾病。2003 年发表了全球范围内单纯性 OLE 的患病率，而不同研究中的患病率存在差异。近年来，大规模的汇总和定义相关分析没有得到足够的重视。本研究旨在对口腔白斑病的患病率研究进行系统评价，并评估其发生的相关因素。
方法
在数据库（Pubmed、Embase、Scopus 和 Web of Science）中使用检索词（“口腔白斑病”或 OLE 或白斑病）和（患病率或发病率或流行病学）搜索 1996 年 1 月至 2022 年 12 月发表的 OLE 研究。使用 STATA 16.0 进行估计患病率计算和偏倚风险分析。
结果
我们从 28 个国家/地区的 6 个大洲获得了 69 项研究，共纳入 1263028 名参与者。患病率为 1.39%，范围为 0.12%至 33.33%。基于人群的研究中，OLK 的总体汇总估计患病率为 2.23%，基于诊所的人群研究为 1.36%，特定人群为 9.10%。不同大陆的汇总患病率范围为 0.33%至 11.74%，基于人群的计算存在统计学差异。男性的 OLK 患病率高于女性。吸烟者和饮酒者的患病率高于不吸烟者和饮酒者。
结论
综合 69 项已发表研究的数据，OLK 的患病率为 1.39%，全球患病率的汇总估计值为 3.41%。不同大洲和不同定义的患病率相对一致和稳定。男性、60 岁以上、吸烟者和饮酒者的汇总估计患病率较高。本系统评价纳入研究的结果表明，不同定义和大洲的患病率相对一致和稳定，这可能有助于制定全球口腔白斑病的治疗和预防策略。
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