Preciado-Llanes Lorena, Wing James B, Foster Rachel A, Carlring Jennifer, Lees Andrew, Read Robert C, Heath Andrew W
Department of Infection and Immunity, School of Medicine and Biomedical Sciences, The University of Sheffield, Sheffield, S102RX, United Kingdom.
Immunology. 2014 Sep 20;144(3):444-52. doi: 10.1111/imm.12389.
Although the co-stimulatory interaction between B and T cells is well defined, recent evidence suggests that B cells also have a regulatory role. Here, we show that B cells activated using anti-IgD conjugated to dextran (α-δ-dex) directly inhibit TCR-induced CD4 T cell activation, proliferation and cytokine production. This effect was observed in CD4 T cells activated both with and without CD28 co-stimulation. T cell viability was unaffected, and the T cell suppressive effect was mediated by contact with IgD activated purified B cells and not by IL-10 or other soluble factors. This is the first evidence of IgD activated B cells mediating inhibition of activation and proliferation of CD4 T cells in humans. This article is protected by copyright. All rights reserved.
尽管B细胞与T细胞之间的共刺激相互作用已得到充分明确，但最近的证据表明B细胞也具有调节作用。在此，我们表明，使用与葡聚糖偶联的抗IgD（α-δ-葡聚糖）激活的B细胞可直接抑制TCR诱导的CD4 T细胞活化、增殖和细胞因子产生。在有和没有CD28共刺激的情况下激活的CD4 T细胞中均观察到这种效应。T细胞活力未受影响，且T细胞抑制作用是通过与IgD激活的纯化B细胞接触介导的，而非由IL-10或其他可溶性因子介导。这是IgD激活的B细胞介导抑制人类CD4 T细胞活化和增殖的首个证据。本文受版权保护。保留所有权利。
