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C 群脑膜炎球菌结合疫苗反应与 B 细胞和 T 细胞活性的相关性。

Correlation of group C meningococcal conjugate vaccine response with B- and T-lymphocyte activity.

机构信息

Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, United Kingdom.

出版信息

PLoS One. 2012;7(2):e31160. doi: 10.1371/journal.pone.0031160. Epub 2012 Feb 8.

DOI:10.1371/journal.pone.0031160
PMID:22347446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3275607/
Abstract

Despite the success of conjugate vaccination against meningococcal group C (MenC) disease, post-vaccination, some individuals still exhibit rapid waning of initially protective bactericidal antibody levels. The mechanism of this relative loss of humoral protection remains undetermined. In this report we have investigated the relationship between T- and B-cell activation and co-stimulation and the loss of protective antibody titers. We have found that healthy volunteers who lose protective MenC antibody levels one year after receipt of glycoconjugate vaccine exhibit no detectable cellular defect in polyclonal B- or T-cell activation, proliferation or the B-memory pool. This suggests that the processes underlying the more rapid loss of antibody levels are independent of defects in either initial T- or B-cell activation.

摘要

尽管针对脑膜炎球菌 C 群（MenC）疾病的结合疫苗取得了成功，但在接种疫苗后，一些人仍然表现出最初保护性杀菌抗体水平的快速下降。这种相对丧失体液保护的机制仍未确定。在本报告中，我们研究了 T 细胞和 B 细胞活化和共刺激与保护性抗体滴度丧失之间的关系。我们发现，在接种糖缀合疫苗一年后失去保护性 MenC 抗体水平的健康志愿者，其多克隆 B 或 T 细胞活化、增殖或 B 细胞记忆库中没有检测到细胞缺陷。这表明，导致抗体水平更快下降的过程与初始 T 细胞或 B 细胞活化缺陷无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/107f/3275607/d0e66615bffb/pone.0031160.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/107f/3275607/f919a9c4989b/pone.0031160.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/107f/3275607/e2691841fe3b/pone.0031160.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/107f/3275607/d0e66615bffb/pone.0031160.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/107f/3275607/f919a9c4989b/pone.0031160.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/107f/3275607/e2691841fe3b/pone.0031160.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/107f/3275607/d0e66615bffb/pone.0031160.g003.jpg

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2
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3
Functional T-cell deficiency in adolescents who experience serogroup C meningococcal disease despite receiving the meningococcal serogroup C conjugate vaccine.
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Clin Vaccine Immunol. 2010 Jul;17(7):1104-10. doi: 10.1128/CVI.00481-09. Epub 2010 May 12.
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B-cell-T-cell activation and interaction in common variable immunodeficiency.常见变异性免疫缺陷中的 B 细胞-T 细胞激活和相互作用。
Hum Immunol. 2010 Apr;71(4):355-62. doi: 10.1016/j.humimm.2010.01.019. Epub 2010 Feb 19.
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