无金属氧化异腈与芳香醛插入反应合成芳酰化氮杂环化合物
Metal-free oxidative isocyanides insertion with aromatic aldehydes to aroylated N-heterocycles.
作者信息
He Yimiao, Wang Xuelian, Xiao Jun-An, Pang Jinying, Gan Chunfang, Huang Yanmin, Huang Chusheng
机构信息
College of Chemistry and Materials Science, Guangxi Teachers Education University Nanning 530001 P. R. China
出版信息
RSC Adv. 2018 Jan 15;8(6):3036-3040. doi: 10.1039/c7ra12755c. eCollection 2018 Jan 12.
Abstract
A metal-free, mild and efficient protocol for the construction of aroylated N-heterocycles radical cascade aroylation of phenyl or vinyl isocyanides with aromatic aldehydes has been developed. Both phenanthridine and isoquinoline derivatives are delivered quickly in moderate to good yields with high regioselectivity.
摘要
已开发出一种无金属、温和且高效的构建芳酰化氮杂环的方法，即通过苯基或乙烯基异腈与芳香醛的自由基级联芳酰化反应。菲啶和异喹啉衍生物均能快速以中等至良好的产率和高区域选择性得到。
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