Swanson L W
Ciba Found Symp. 1977(58):25-48. doi: 10.1002/9780470720394.ch4.
Since the time of Elliot Smith (1910) it has been recognized that the septal complex occupies a pivotal position within the mammalian telencephalon, being strategically placed between the hippocampal formation on the one hand and the basal forebrain and diencephalon on the other. However, it is only in the last few years that the detailed interrelationships between the different nuclear groups within the septum and the various subfields of the hippocampus have been studied. We have recently re-examined the connections of both the septum and the hippocampal formation using the techniques based on the anterograde transport of isotopically labelled proteins and the retrograde transport of the enzyme marker, horseradish peroxidase. Our findings may be summarized as follows. Field CA1 of Ammon's horn and the adjoining subiculum project through the fimbria and pre-commissural fornix upon the lateral septal nucleus of the same side in a topographically ordered manner. Field CA3, on the other hand, projects bilaterally upon the lateral septum. The lateral septal nucleus in turn, projects partly upon the medial septal nucleus and nucleus of the diagonal band, and partly to the lateral hypothalamus and the mamillary complex. The medial septal-diagonal band complex projects back, through the fimbria and dorsal fornix, to fields CA3 and CA4 of the hippocampus, to the dentate gyrus, to the subicular complex, and to the entorhinal area. The subicular complex projects through the post-commissural fornix to the anterior thalamic group, the mamillary complex, and the ventromedial and arcuate nuclei of the hypothalamus. Ammon's horn and the subiculum also project to the posterior septal nuclei (triangular and septofimbrial), which in turn send their output to the habenular and interpeduncular nuclei. The significance of these projections is analysed in a review of the major known afferent and efferent connections of the septum and hippocampus, and the cell groups to which they project directly.
自艾略特·史密斯（1910年）时代起，人们就认识到隔区复合体在哺乳动物端脑中占据关键位置，它一方面位于海马结构与另一方面的基底前脑和间脑之间，位置至关重要。然而，直到最近几年，才开始研究隔区内不同核团与海马各个亚区之间的详细相互关系。我们最近利用基于同位素标记蛋白质顺行运输和酶标辣根过氧化物酶逆行运输的技术，重新研究了隔区和海马结构的连接。我们的研究结果可总结如下。海马角的CA1区和相邻的下托通过穹窿和连合前穹窿，以拓扑有序的方式投射到同侧的外侧隔核。另一方面，CA3区双侧投射到外侧隔区。外侧隔核反过来，部分投射到内侧隔核和斜角带核，部分投射到外侧下丘脑和乳头复合体。内侧隔 - 斜角带复合体通过穹窿和背侧穹窿，反向投射到海马的CA3区和CA4区、齿状回、下托复合体和内嗅区。下托复合体通过连合后穹窿投射到丘脑前组、乳头复合体以及下丘脑的腹内侧核和弓状核。海马角和下托也投射到后隔核（三角形核和隔 - 穹窿核），而后隔核又将其输出发送到缰核和脚间核。在回顾隔区和海马的主要已知传入和传出连接以及它们直接投射的细胞群时，分析了这些投射的意义。
