School of Psychology, Cardiff University, 70 Park Place, Cardiff, CF10 3AT, Wales, UK.
School of Psychology and Institute of Neuroscience, Trinity College, Dublin, Ireland.
Neurosci Biobehav Rev. 2020 Dec;119:268-280. doi: 10.1016/j.neubiorev.2020.10.006. Epub 2020 Oct 16.
Two thalamic sites are of especial significance for understanding hippocampal - diencephalic interactions: the anterior thalamic nuclei and nucleus reuniens. Both nuclei have dense, direct interconnections with the hippocampal formation, and both are directly connected with many of the same cortical and subcortical areas. These two thalamic sites also contain neurons responsive to spatial stimuli while lesions within these two same areas can disrupt spatial learning tasks that are hippocampal dependent. Despite these many similarities, closer analysis reveals important differences in the details of their connectivity and the behavioural impact of lesions in these two thalamic sites. These nuclei play qualitatively different roles that largely reflect the contrasting relative importance of their medial frontal cortex interactions (nucleus reuniens) compared with their retrosplenial, cingulate, and mammillary body interactions (anterior thalamic nuclei). While the anterior thalamic nuclei are critical for multiple aspects of hippocampal spatial encoding and performance, nucleus reuniens contributes, as required, to aid cognitive control and help select correct from competing memories.
两个丘脑部位对于理解海马体-间脑相互作用尤为重要：前丘脑核和丘脑后连合核。这两个核都与海马结构有密集的直接联系，并且都与许多相同的皮质和皮质下区域直接相连。这两个丘脑部位还包含对空间刺激有反应的神经元，而这两个相同区域内的损伤会破坏依赖于海马体的空间学习任务。尽管有许多相似之处，但更仔细的分析揭示了它们连接的细节以及这两个丘脑部位损伤的行为影响方面的重要差异。这些核发挥着不同的作用，这在很大程度上反映了它们与额内侧皮质相互作用（丘脑后连合核）的相对重要性与它们与后扣带回、扣带回和乳头体相互作用（前丘脑核）的对比。虽然前丘脑核对于海马体空间编码和表现的多个方面都很关键，但丘脑后连合核在需要时有助于认知控制并帮助从竞争记忆中选择正确的记忆。
