Kwon Yong-Soo, Kim Yee Hyung, Song Jae-Uk, Jeon Kyeongman, Song Junwhi, Ryu Yon Ju, Choi Jae Chol, Kim Ho Cheol, Koh Won-Jung
Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea.
Department of Pulmonary and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, Korea.
J Korean Med Sci. 2014 Sep;29(9):1226-31. doi: 10.3346/jkms.2014.29.9.1226. Epub 2014 Sep 2.
The data regarding risk factors for death during tuberculosis (TB) treatment are inconsistent, and few studies examined this issue in Korea. The purpose of this study was to evaluate baseline prognostic factors for death during treatment of adult patients with pulmonary TB in Korea. A multicenter retrospective cohort study of 2,481 patients who received TB treatment at eight hospitals from January 2009 to December 2010 was performed. Successful treatment included cure (1,129, 45.5%) and treatment completion (1,204, 48.5%) in 2,333 patients (94.0%). Unsuccessful treatment included death (85, 3.4%) and treatment failure (63, 2.5%) occurred in 148 patients (6.0%). In multivariate analysis, male sex, anemia, dyspnea, chronic heart disease, malignancy, and intensive care unit (ICU) admission were significant risk factors for death during TB treatment. Therefore, male sex, anemia, dyspnea, chronic heart disease, malignancy, and ICU admission could be baseline prognostic factors for death during treatment of adult patients with pulmonary TB in Korea.
关于结核病（TB）治疗期间死亡风险因素的数据并不一致，在韩国很少有研究探讨这个问题。本研究的目的是评估韩国成年肺结核患者治疗期间死亡的基线预后因素。对2009年1月至2010年12月期间在八家医院接受结核病治疗的2481例患者进行了一项多中心回顾性队列研究。2333例患者（94.0%）的成功治疗包括治愈（1129例，45.5%）和完成治疗（1204例，48.5%）。148例患者（6.0%）的治疗失败包括死亡（85例，3.4%）和治疗失败（63例，2.5%）。在多变量分析中，男性、贫血、呼吸困难、慢性心脏病、恶性肿瘤和入住重症监护病房（ICU）是结核病治疗期间死亡的显著风险因素。因此，男性、贫血、呼吸困难、慢性心脏病、恶性肿瘤和入住ICU可能是韩国成年肺结核患者治疗期间死亡的基线预后因素。
