Lee Yoo Jin, Park Kyung Sik, Cho Kwang Bum, Kim Eun Soo, Jang Byoung Kuk, Chung Woo Jin, Hwang Jae Seok
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
J Korean Med Sci. 2014 Sep;29(9):1247-52. doi: 10.3346/jkms.2014.29.9.1247. Epub 2014 Sep 2.
Only a few studies have evaluated the population-adjusted prevalence of gallbladder polyps (GBP). This study aimed to evaluate the changes in GBP prevalence and risk factors at a single health screening center in Korea from 2002 to 2012. Of 48,591 adults who underwent health screening between 2002 and 2012, 14,250 age- and gender-matched subjects were randomly selected to evaluate prevalence. Risk factors were analyzed between the GBP-positive and GBP-negative groups during 2002-2004 (Period A) and 2010-2012 (Period B). The annual prevalence of GBP over the 11-yr period was 5.4%. Annual prevalence increased from 3.8% in Period A to 7.1% in Period B. Male gender and obesity were independent risk factors for GBP in both periods. Hepatitis B virus surface antigen (HBsAg) positivity was a risk factor for GBP in Period A but not in Period B. The risk factors for GBP changed from HBsAg positivity to lipid profile abnormalities. Other variables including age, hypertension, diabetes, impaired fasting glucose, chronic hepatitis C virus infection, and liver function tests did not correlate with GBP. In conclusion, GBP prevalence is increasing and risk factors for GBP have changed in Korea. More attention should be paid to this issue in the future.
仅有少数研究评估了经人群调整后的胆囊息肉（GBP）患病率。本研究旨在评估2002年至2012年韩国某单一健康筛查中心GBP患病率的变化及危险因素。在2002年至2012年接受健康筛查的48591名成年人中，随机选取14250名年龄和性别匹配的受试者来评估患病率。对2002 - 2004年（A期）和2010 - 2012年（B期）GBP阳性组和GBP阴性组之间的危险因素进行了分析。11年期间GBP的年患病率为5.4%。年患病率从A期的3.8%升至B期的7.1%。男性和肥胖在两个时期都是GBP的独立危险因素。乙肝表面抗原（HBsAg）阳性在A期是GBP的危险因素，但在B期不是。GBP的危险因素从HBsAg阳性转变为血脂异常。包括年龄、高血压、糖尿病、空腹血糖受损、慢性丙型肝炎病毒感染和肝功能检查在内的其他变量与GBP无关。总之，韩国的GBP患病率在上升，且GBP的危险因素已发生变化。未来应更加关注这一问题。
