Deparment of Neurology, Medical Faculty, Bezmialem Vakıf University, Istanbul, Turkey.
Department of Psychiatry, Bakırköy Research and Training Hospital for Psychiatry, Istanbul, Turkey.
Neuropsychiatr Dis Treat. 2014 Sep 10;10:1715-9. doi: 10.2147/NDT.S68389. eCollection 2014.
Although smoking is known to cause various symptoms in multiple sclerosis (MS) patients, there have been no reports regarding the relationship between smoking and cognitive impairment in MS. Studying the effects of cigarette smoking in MS patients is imperative as there is a high prevalence of cognitive impairment in MS patients. In this study we examined the potentially deleterious effects of heavy smoking on mentation of patients with MS.
MS patients receiving care at the Neurology Clinic at Bezmialem Vakıf University, between the ages of 18-65 years who have at least graduated elementary school were included in the study. The Brief Repeatable Battery of Neuropsychological Tests (BRB-N) is a commonly used method to assess cognitive function in MS patients and was utilized in our study. Patients that smoked for at least 10 pack-years were considered heavy smokers.
ALL THE PATIENTS WERE STRATIFIED INTO TWO GROUPS: heavy smokers (n=20) and nonsmokers (n=24). For heavy smokers, their cognitive functioning was more impaired than that of nonsmokers (P=0.04, χ (2)=4.227). For patients with cognitive impairment, 78.9% of the Paced Auditory Serial Addition Test and 63.2% of the Symbol Digit Modalities Test scores were found to be lower.
Previous reports have suggested that smoking increases the frequency of relapse among individuals with relapsing-remitting MS and accelerates disease progression in patients with progressive MS. According to the results of our study, heavy smokers had increased cognitive impairment when compared to nonsmokers. Extensive studies are necessary to further elucidate the relationship between smoking and cognitive impairment in MS patients.
虽然吸烟已知会引起多发性硬化症（MS）患者出现各种症状，但尚无关于吸烟与 MS 认知障碍之间关系的报告。由于 MS 患者认知障碍的患病率很高，因此研究吸烟对 MS 患者的影响至关重要。在这项研究中，我们检查了重度吸烟对 MS 患者思维的潜在有害影响。
本研究纳入了在贝济米耶勒法提赫大学神经科诊所就诊的年龄在 18-65 岁之间、至少受过小学教育的 MS 患者。BRB-N 是一种常用于评估 MS 患者认知功能的常用方法，我们在研究中使用了该方法。吸烟至少 10 包年的患者被认为是重度吸烟者。
所有患者均分为两组：重度吸烟者（n=20）和非吸烟者（n=24）。与非吸烟者相比，重度吸烟者的认知功能受损更严重（P=0.04，χ²=4.227）。对于认知障碍患者，发现 78.9%的听觉连续加法测试和 63.2%的符号数字模态测试得分较低。
先前的报告表明，吸烟会增加缓解复发型 MS 患者的复发频率，并加速进展型 MS 患者的疾病进展。根据我们的研究结果，与不吸烟者相比，重度吸烟者的认知障碍程度更高。需要进行广泛的研究来进一步阐明吸烟与 MS 患者认知障碍之间的关系。
