氟化δ-内酰胺的简短高效合成
Short and efficient synthesis of fluorinated δ-lactams.
作者信息
Cogswell Thomas J, Donald Craig S, Long De-Liang, Marquez Rodolfo
机构信息
School of Chemistry, University of Glasgow, Glasgow, G12 8QQ, UK.
出版信息
Org Biomol Chem. 2015 Jan 21;13(3):717-28. doi: 10.1039/c4ob01547a.
PMID:25247464
Abstract
The diastereoselective synthesis of fluorinated δ-lactams has been achieved through an efficient five step process. The route can tolerate a range of functionalities, and provides a quick route for the generation of new fluorinated medicinal building blocks.
摘要
通过一个高效的五步过程实现了氟化δ-内酰胺的非对映选择性合成。该路线能够耐受一系列官能团，并为生成新的氟化药用结构单元提供了一条快速途径。
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