二氢吡啶酮合成的快速双釜法；氮杂戈尼他明的全合成。
Rapid, two-pot procedure for the synthesis of dihydropyridinones; total synthesis of aza-goniothalamin.
作者信息
Cogswell Thomas J, Donald Craig S, Marquez Rodolfo
机构信息
School of Chemistry, University of Glasgow, Glasgow, G12 8QQ, U.K.
Lucideon Limited., Queens Road, Penkhull, Stoke-on-Trent, Staffordshire, ST4 7LQ, U.K.
出版信息
Beilstein J Org Chem. 2020 Jan 28;16:135-139. doi: 10.3762/bjoc.16.15. eCollection 2020.
Abstract
A fast, protecting-group-free synthesis of dihydropyridinones has been developed. Starting from commercially available aldehydes, a novel one-pot amidoallylation gave access to diene compounds in good yields. Ring-closing metathesis conditions were then employed to produce the target dihydropyridinones efficiently and in high yields.
摘要
已开发出一种快速、无需保护基团的二氢吡啶酮合成方法。从市售醛开始，一种新颖的一锅法酰胺烯丙基化反应能够以良好的产率得到二烯化合物。然后采用闭环复分解反应条件高效、高产率地制备目标二氢吡啶酮。
Zotero 插件