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Cytarabine preferentially induces mutation at specific sequences in the genome which are identifiable in relapsed acute myeloid leukaemia.

作者信息

Fordham S E, Cole M, Irving J A, Allan J M

机构信息

Newcastle Cancer Centre, Northern Institute for Cancer Research, Paul O'Gorman Building, Newcastle University, Newcastle-upon-Tyne, UK.

出版信息

Leukemia. 2015 Feb;29(2):491-4. doi: 10.1038/leu.2014.284. Epub 2014 Sep 24.

DOI:10.1038/leu.2014.284
PMID:25249014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4320285/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f6f/4320285/bdda1987f12b/leu2014284f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f6f/4320285/bdda1987f12b/leu2014284f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f6f/4320285/bdda1987f12b/leu2014284f1.jpg

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Nature. 2012 Jan 11;481(7382):506-10. doi: 10.1038/nature10738.
3
TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics.TET2 突变是中危细胞遗传学急性髓系白血病患者的不良预后因素。
跨损伤合成 DNA 聚合酶 η、ι 和 ν 通过抗癌核苷胞苷促进诱变复制。
J Biol Chem. 2019 Dec 13;294(50):19048-19054. doi: 10.1074/jbc.RA119.011381. Epub 2019 Nov 4.
4
Clonal evolution of acute myeloid leukemia from diagnosis to relapse.从诊断到复发的急性髓系白血病的克隆进化。
Genes Chromosomes Cancer. 2019 Dec;58(12):839-849. doi: 10.1002/gcc.22806. Epub 2019 Sep 3.
5
The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia.CHK1 抑制剂与 G-CSF 的联合应用克服了人急性髓系白血病中阿糖胞苷的耐药性。
Nat Commun. 2017 Nov 22;8(1):1679. doi: 10.1038/s41467-017-01834-4.
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FNC efficiently inhibits mantle cell lymphoma growth.FNC能有效抑制套细胞淋巴瘤的生长。
PLoS One. 2017 Mar 23;12(3):e0174112. doi: 10.1371/journal.pone.0174112. eCollection 2017.
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Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation.小儿T细胞淋巴母细胞白血病通过克隆选择、获得突变和启动子低甲基化演变为复发。
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