阿糖胞苷优先诱导基因组中特定序列发生突变，这些序列在复发的急性髓系白血病中是可识别的。 - Suppr

Cytarabine preferentially induces mutation at specific sequences in the genome which are identifiable in relapsed acute myeloid leukaemia.

作者信息

Fordham S E, Cole M, Irving J A, Allan J M

机构信息

Newcastle Cancer Centre, Northern Institute for Cancer Research, Paul O'Gorman Building, Newcastle University, Newcastle-upon-Tyne, UK.

出版信息

Leukemia. 2015 Feb;29(2):491-4. doi: 10.1038/leu.2014.284. Epub 2014 Sep 24.

DOI:10.1038/leu.2014.284

PMID:25249014

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4320285/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f6f/4320285/bdda1987f12b/leu2014284f1.jpg

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Cytarabine preferentially induces mutation at specific sequences in the genome which are identifiable in relapsed acute myeloid leukaemia.阿糖胞苷优先诱导基因组中特定序列发生突变，这些序列在复发的急性髓系白血病中是可识别的。

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本文引用的文献

Clonal architecture of secondary acute myeloid leukemia.继发性急性髓系白血病的克隆结构。

N Engl J Med. 2012 Mar 22;366(12):1090-8. doi: 10.1056/NEJMoa1106968. Epub 2012 Mar 14.

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing.全基因组测序揭示复发急性髓系白血病的克隆进化。

Nature. 2012 Jan 11;481(7382):506-10. doi: 10.1038/nature10738.

TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics.TET2 突变是中危细胞遗传学急性髓系白血病患者的不良预后因素。

Blood. 2011 Oct 6;118(14):3803-10. doi: 10.1182/blood-2011-02-339747. Epub 2011 Aug 9.

Cytarabine dose for acute myeloid leukemia.阿糖胞苷剂量治疗急性髓系白血病。

N Engl J Med. 2011 Mar 17;364(11):1027-36. doi: 10.1056/NEJMoa1010222.

DNA mismatch repair status affects cellular response to Ara-C and other anti-leukemic nucleoside analogs.DNA错配修复状态影响细胞对阿糖胞苷及其他抗白血病核苷类似物的反应。

Leukemia. 2011 Jun;25(6):1046-9. doi: 10.1038/leu.2011.38. Epub 2011 Mar 4.

Therapeutic advances in acute myeloid leukemia.急性髓细胞白血病的治疗进展。

J Clin Oncol. 2011 Feb 10;29(5):487-94. doi: 10.1200/JCO.2010.30.1820. Epub 2011 Jan 10.

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer.小鼠Msh2基因的失活会导致错配修复缺陷、甲基化耐受、高重组率以及易患癌症。

Cell. 1995 Jul 28;82(2):321-30. doi: 10.1016/0092-8674(95)90319-4.

Mutation assay at the thymidine kinase locus in diploid human lymphoblasts.二倍体人类淋巴母细胞胸苷激酶基因座的突变检测

Mutat Res. 1982 Jun;94(2):467-85. doi: 10.1016/0027-5107(82)90308-6.

Studies in mouse L-cells on the incorporation of 1-beta-D-arabinofuranosylcytosine into DNA and on inhibition of DNA polymerase by 1-beta-D-arabinofuranosylcytosine 5'-triphosphate.关于1-β-D-阿拉伯呋喃糖基胞嘧啶掺入小鼠L细胞DNA以及5'-三磷酸1-β-D-阿拉伯呋喃糖基胞嘧啶对DNA聚合酶抑制作用的研究。

Cancer Res. 1970 Nov;30(11):2636-44.

Action of 1- -D-arabinofuranosylcytosine on mammalian tumor cells. 1. Incorporation into DNA.

Eur J Cancer (1965). 1972 Aug;8(4):391-6. doi: 10.1016/0014-2964(72)90122-3.

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Cytarabine preferentially induces mutation at specific sequences in the genome which are identifiable in relapsed acute myeloid leukaemia.

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