Holt Edward W, Wei Esther K, Bennett Nancy, Zhang Laura M
Department of Transplantation, Division of Hepatology, California Pacific Medical Center, San Francisco, CA.
Research Institute, California Pacific Medical Center, San Francisco, CA.
Nutr Res. 2014 Oct;34(10):821-6. doi: 10.1016/j.nutres.2014.08.017. Epub 2014 Sep 6.
Oxidative stress is increased in patients with metabolic syndrome (MS). Antioxidants, including carotenoids, are decreased in MS. We hypothesized that a low skin carotenoid score (SCS), calculated using resonance Raman spectroscopy, would correlate with the presence of MS. We retrospectively reviewed consecutive patients referred for dietary assessment between 2010 and 2012. For each patient, a nutrition history, medical history, and SCS were recorded. χ(2) and Student t test were used to determine factors associated with MS. Multivariate logistic regression was used to identify factors associated with MS. One hundred fifty-five patients were included. The mean age was 54.1 ± 13.1 years, and the mean body mass index was 28.3 ± 6.1 kg/m(2). Metabolic syndrome was present in 43.9% of patients. The mean SCS was 28 084 ± 14 006 Raman counts (RC), including 23 058 ± 9812 RC for patients with MS and 32 011 ± 15 514 RC for patients without MS (P = .0001). In a multivariate analysis, SCS less than 25 000 RC (odds ratio, 3.71; 95% confidence interval, 1.36-10.7; P = .01) was independently associated with MS. A higher number of MS components was associated with a progressively lower SCS (P = .004). In a consecutive sample of patients referred for dietary assessment, a noninvasively measured SCS was lower among patients with MS.
代谢综合征（MS）患者的氧化应激水平升高。包括类胡萝卜素在内的抗氧化剂在MS患者体内减少。我们推测，使用共振拉曼光谱法计算得出的低皮肤类胡萝卜素评分（SCS）与MS的存在相关。我们回顾性分析了2010年至2012年间因饮食评估而转诊的连续患者。记录了每位患者的营养史、病史和SCS。采用χ²检验和学生t检验来确定与MS相关的因素。使用多因素逻辑回归来识别与MS相关的因素。共纳入155例患者。平均年龄为54.1±13.1岁，平均体重指数为28.3±6.1kg/m²。43.9%的患者患有代谢综合征。平均SCS为28084±14006拉曼计数（RC），其中MS患者为23058±9812RC，无MS患者为32011±15514RC（P = 0.0001）。在多因素分析中，SCS低于25000RC（比值比，3.71；95%置信区间，1.36 - 10.7；P = 0.01）与MS独立相关。MS组分数量越多，SCS越低（P = .004）。在因饮食评估而转诊的连续患者样本中，MS患者的无创测量SCS较低。
