Mizuno Yuko, Purcell David W, Knowlton Amy R, Wilkinson James D, Gourevitch Marc N, Knight Kelly R
Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, NE Mail Stop E37, Atlanta, GA, 30333, USA,
AIDS Behav. 2015 Apr;19(4):684-93. doi: 10.1007/s10461-014-0890-0.
Limited investigations have been conducted on syndemics and HIV continuum of care outcomes. Using baseline data from a multi-site, randomized controlled study of HIV-positive injection drug users (n = 1,052), we examined whether psychosocial factors co-occurred, and whether these factors were additively associated with behavioral and HIV continuum of care outcomes. Experiencing one type of psychosocial problem was significantly (p < 0.05) associated with an increased odds of experiencing another type of problem. Persons with 3 or more psychosocial problems were significantly more likely to report sexual and injection risk behaviors and were less likely to be adherent to HIV medications. Persons with 4 or more problems were less likely to be virally suppressed. Reporting any problems was associated with not currently taking HIV medications. Our findings highlight the association of syndemics not only with risk behaviors, but also with outcomes related to the continuum of care for HIV-positive persons.
关于综合征以及艾滋病病毒连续护理结果的调查有限。利用一项针对艾滋病毒呈阳性的注射吸毒者的多地点随机对照研究（n = 1052）的基线数据，我们研究了社会心理因素是否同时出现，以及这些因素是否与行为和艾滋病病毒连续护理结果存在累加关联。经历一种社会心理问题与经历另一种问题的几率增加显著相关（p < 0.05）。有3种或更多社会心理问题的人更有可能报告性和注射风险行为，且坚持服用艾滋病毒药物的可能性较小。有4种或更多问题的人病毒抑制的可能性较小。报告任何问题都与目前未服用艾滋病毒药物有关。我们的研究结果突出了综合征不仅与风险行为有关，还与艾滋病毒呈阳性者连续护理的结果有关。
