Department of Emergency Medicine, Brigham and Women's Hospital, 75 Francis St, Boston, MA, 02115, USA.
Department of Psychiatry, Massachusetts General Hospital, Boston, USA.
J Med Toxicol. 2024 Apr;20(2):205-214. doi: 10.1007/s13181-024-01000-5. Epub 2024 Mar 4.
Digital phenotyping is a process that allows researchers to leverage smartphone and wearable data to explore how technology use relates to behavioral health outcomes. In this Research Concepts article, we provide background on prior research that has employed digital phenotyping; the fundamentals of how digital phenotyping works, using examples from participant data; the application of digital phenotyping in the context of substance use and its syndemics; and the ethical, legal and social implications of digital phenotyping. We discuss applications for digital phenotyping in medical toxicology, as well as potential uses for digital phenotyping in future research. We also highlight the importance of obtaining ground truth annotation in order to identify and establish digital phenotypes of key behaviors of interest. Finally, there are many potential roles for medical toxicologists to leverage digital phenotyping both in research and in the future as a clinical tool to better understand the contextual features associated with drug poisoning and overdose. This article demonstrates how medical toxicologists and researchers can progress through phases of a research trajectory using digital phenotyping to better understand behavior and its association with smartphone usage.
数字表型是一种利用智能手机和可穿戴设备数据来探索技术使用如何与行为健康结果相关的过程。在这篇研究概念文章中，我们提供了先前使用数字表型的研究背景；使用参与者数据示例介绍数字表型的工作原理；数字表型在物质使用及其综合征学背景下的应用；以及数字表型的伦理、法律和社会影响。我们讨论了数字表型在医疗毒理学中的应用，以及数字表型在未来研究中的潜在用途。我们还强调了获取地面真实注释以识别和建立关键行为的数字表型的重要性。最后，医疗毒理学家有许多潜在的角色可以利用数字表型，无论是在研究中还是在未来作为一种临床工具，以更好地了解与药物中毒和过量相关的上下文特征。本文展示了医疗毒理学家和研究人员如何通过使用数字表型来理解行为及其与智能手机使用的关联，从而在研究中逐步推进研究轨迹。
