Motalleb Gholamreza
Dept. of Biology, Faculty of Science, University of Zabol, Zabol, Iran.
Iran J Cancer Prev. 2013 Spring;6(2):101-7.
New cancer therapies with novel mechanisms and functions are needed to treatpatients with different cancers. Virotherapy is a good scenario for such treatment. The advantages of virotherapy include the potential lack of cross resistance with standard therapies and the ability to cause tumor destruction by numerous mechanisms. Oncolytic virus not only possesses unique mechanisms of action that are distinct from other treatment modalities, its self-perpetuating nature provides an ideal platform for therapeutic transgenic insertion. In this review article, a variety of oncolytic viruses in cancer gene therapy will be described.
需要具有新颖机制和功能的新型癌症疗法来治疗不同癌症患者。病毒疗法是这种治疗的一个良好方案。病毒疗法的优点包括可能与标准疗法不存在交叉耐药性，以及能够通过多种机制导致肿瘤破坏。溶瘤病毒不仅具有与其他治疗方式不同的独特作用机制，其自我增殖的特性为治疗性转基因插入提供了理想平台。在这篇综述文章中，将描述癌症基因治疗中多种溶瘤病毒。
