Ma Guoda, Yin Jingwen, Fu Jiawu, Luo Xudong, Zhou Haihong, Tao Hua, Cui Lili, Li You, Lin Zhixiong, Zhao Bin, Li Zheng, Lin Juda, Li Keshen
Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China.
Department of Psychiatry, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
Biomed Res Int. 2014;2014:751267. doi: 10.1155/2014/751267. Epub 2014 Aug 27.
Both genome wide association study (GWAS) and biochemical studies of Caucasian populations indicate a robust association between the miR-137 genetic variant rs1625579 and schizophrenia, but inconsistent results have been reported. To assay the association between this variant and schizophrenia, we genotyped 611 schizophrenic patients from Southern Chinese Han population for the risk single nucleotide polymorphism (SNP) rs1625579 using the SNaPshot technique and compared the clinical profiles of different genotypes. Additionally, a meta-analysis was performed using the combined sample groups from five case-control publications and the present study. Both the genotype and allele distributions of the rs1625579 SNP were significantly different between patients and controls (P = 0.036 and 0.026, SNP). TT genotype carriers showed slightly lower Brief Assessment of Cognition in Schizophrenia- (BACS-) derived working memory performance than G carriers (15.58 ± 9.56 versus 19.71 ± 8.18, P = 0.045). In the meta-analysis, we observed a significant association between rs1625579 and schizophrenia under different genetic models (all P < 0.05). The results of our study and meta-analysis provide convincing evidence that rs1625579 is significantly associated with schizophrenia. Furthermore, the miR-137 polymorphism influences the working memory performance of schizophrenic patients in a Chinese Han population.
全基因组关联研究（GWAS）以及针对高加索人群的生化研究均表明，miR - 137基因变异体rs1625579与精神分裂症之间存在紧密关联，但也有不一致的研究结果报道。为了分析该变异体与精神分裂症之间的关联，我们运用SNaPshot技术对来自中国南方汉族人群的611例精神分裂症患者进行了风险单核苷酸多态性（SNP）rs1625579的基因分型，并比较了不同基因型的临床特征。此外，我们使用了来自五篇病例对照研究出版物以及本研究的合并样本组进行了荟萃分析。rs1625579 SNP的基因型和等位基因分布在患者和对照之间存在显著差异（P = 0.036和0.026，SNP）。TT基因型携带者在基于精神分裂症认知简短评估（BACS）得出的工作记忆表现上略低于G基因型携带者（15.58 ± 9.56对19.71 ± 8.18，P = 0.045）。在荟萃分析中，我们观察到在不同遗传模型下rs1625579与精神分裂症之间存在显著关联（所有P < 0.05）。我们的研究和荟萃分析结果提供了令人信服的证据，表明rs1625579与精神分裂症显著相关。此外，miR - 137多态性影响了中国汉族人群中精神分裂症患者的工作记忆表现。
