miR-137基因中的单核苷酸多态性rs1625579与中国人群精神分裂症风险的meta分析。
The SNP rs1625579 in miR-137 gene and risk of schizophrenia in Chinese population: A meta-analysis.
作者信息
Zhang Ping, Bian Yi, Liu Na, Tang Yingxin, Pan Chao, Hu Yang, Tang Zhouping
机构信息
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.
Department of Emergency, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.
出版信息
Compr Psychiatry. 2016 May;67:26-32. doi: 10.1016/j.comppsych.2016.02.009. Epub 2016 Feb 12.
BACKGROUND
Schizophrenia is a severe psychiatric disorder with a high heritability. A single nucleotide polymorphism (SNP) rs1625579 (G/T; T is the common and presumed risk allele) within an intron of miR-137 gene has been recently suggested to contribute to the susceptibility to schizophrenia by a large-scale genome-wide association study (GWAS) in a sample of predominantly European ancestry. However, subsequent genetic association studies in Chinese population yielded inconsistent results.
METHODS
A meta-analysis reporting the association between rs1625579 and schizophrenia in Chinese population was carried out, pooling 4 eligible case-control studies involving 2847 patients and 3018 controls.
RESULTS
This meta-analysis demonstrated a significant association between rs1625579 and schizophrenia under the allele model [T versus G, odds ratio (OR):1.20, 95% confidence interval (CI): 1.06-1.36] and the recessive model (TT versus GT+GG; OR: 1.19; 95% CI: 1.04-1.37). Additionally, a marginal significant association under the additive model (TT versus GG; OR: 1.64; 95% CI: 1.00-2.69) was observed. However, no significant association was observed under the dominant model (TT+GT versus GG; OR: 1.58; 95% CI: 0.97-2.59).
CONCLUSIONS
This meta-analysis suggested that the SNP rs1625579 in miR-137 gene might be involved in schizophrenia susceptibility in Chinese Han population.
背景
精神分裂症是一种遗传性很高的严重精神疾病。最近一项针对主要为欧洲血统样本的大规模全基因组关联研究（GWAS）表明，miR-137基因内含子中的单核苷酸多态性（SNP）rs1625579（G/T；T是常见的且被认为是风险等位基因）与精神分裂症易感性有关。然而，随后在中国人群中的基因关联研究结果并不一致。
方法
进行了一项荟萃分析，报告rs1625579与中国人群精神分裂症之间的关联，汇总了4项符合条件的病例对照研究，涉及2847例患者和3018例对照。
结果
该荟萃分析表明，在等位基因模型（T对G，优势比（OR）：1.20，95%置信区间（CI）：1.06 - 1.36）和隐性模型（TT对GT + GG；OR：1.19；95% CI：1.04 - 1.37）下，rs1625579与精神分裂症存在显著关联。此外，在加性模型（TT对GG；OR：1.64；95% CI：1.00 - 2.69）下观察到边缘显著关联。然而，在显性模型（TT + GT对GG；OR：1.58；95% CI：0.97 - 2.59）下未观察到显著关联。
结论
该荟萃分析表明，miR-137基因中的SNP rs1625579可能与中国汉族人群的精神分裂症易感性有关。
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