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耳鼻喉科诊所中的前庭性偏头痛:患病率、相关症状及预防性药物疗效

Vestibular migraine in an otolaryngology clinic: prevalence, associated symptoms, and prophylactic medication effectiveness.

作者信息

Van Ombergen Angelique, Van Rompaey Vincent, Van de Heyning Paul, Wuyts Floris

机构信息

*Antwerp University Research centre for Equilibrium and Aerospace (AUREA), University of Antwerp, Antwerp, Belgium; and †Department of Otorhinolaryngology, Antwerp University Hospital, Antwerp, Belgium.

出版信息

Otol Neurotol. 2015 Jan;36(1):133-8. doi: 10.1097/MAO.0000000000000596.

Abstract

OBJECTIVE

To assess the prevalence of vestibular migraine (VM) in patients consulting to an otolaryngology clinic, the neuro-otological associated symptoms, and the effect of prophylactic antimigrainous medication on VM symptom improvement.

STUDY DESIGN

Retrospective chart review.

SETTING

Tertiary referral otolaryngology clinic.

SUBJECTS AND METHODS

We used the diagnostic criteria from the Bárány Society and the International Headache Society to allocate patients to a subgroup: VM, possible VM, and atypical VM.

MAIN OUTCOME MEASURE

The prevalence of VM, percentages of associated neurotological symptoms, and percentages of effectiveness of prophylactic medication.

RESULTS

Sixty-five (16%) patients were selected from the total patient population (n = 407) from which 4.2% were assigned to the definite VM group, 5.7% to the probable VM group, and 6.1% to the atypical VM group. We found a significantly different distribution between the groups for photophobia (p = 0.035), ear pressure (p = 0.023), and scotoma (p = 0.015). Thirty patients were administered with flunarizine and 68% responded with an improvement in VM symptoms (p < 0.001). For propranolol, 31 patients were treated and there was an improvement of symptoms in 73% (p < 0.001). Remarkable was the fact that these percentages were not significantly different between the subgroups.

CONCLUSION

VM is a common disorder presenting in a dizziness clinic, and detailed history taking is important to assess VM-associated symptoms and thus to prevent underdiagnosis. The latter is very important because our study shows that the majority of patients, regardless of VM subtype, can benefit from a prophylactic treatment, but further prospective studies are necessary.

摘要

目的

评估在耳鼻喉科门诊就诊患者中前庭性偏头痛(VM)的患病率、神经耳科相关症状以及预防性抗偏头痛药物对VM症状改善的效果。

研究设计

回顾性病历审查。

研究地点

三级转诊耳鼻喉科门诊。

研究对象与方法

我们采用巴兰尼协会和国际头痛协会的诊断标准将患者分为亚组:VM、可能的VM和非典型VM。

主要观察指标

VM的患病率、相关神经耳科症状的百分比以及预防性药物治疗的有效率。

结果

从总患者人群(n = 407)中选取了65例(16%)患者,其中4.2%被归入确诊VM组,5.7%被归入可能VM组,6.1%被归入非典型VM组。我们发现畏光(p = 0.035)、耳内压迫感(p = 0.023)和暗点(p = 0.015)在各组之间的分布存在显著差异。30例患者服用了氟桂利嗪,68%的患者VM症状有所改善(p < 0.001)。对于普萘洛尔,31例患者接受了治疗,73%的患者症状得到改善(p < 0.001)。值得注意的是,这些百分比在亚组之间没有显著差异。

结论

VM是眩晕门诊中常见的疾病,详细的病史采集对于评估与VM相关的症状从而预防漏诊非常重要。后者非常重要,因为我们的研究表明,大多数患者,无论VM亚型如何,都能从预防性治疗中获益,但还需要进一步的前瞻性研究。

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