Soriano L F, Piansay-Soriano M E
Davao Doctors Hospital, Davao City, Philippines; Imperial College School of Medicine, London, UK.
Clin Exp Dermatol. 2015 Jan;40(1):23-6. doi: 10.1111/ced.12461. Epub 2014 Sep 23.
Few cases of naevoid hyperkeratosis of the nipple and areola (NHNA) have been documented since the condition was first described in 1923. A recent PubMed search (Mar 2014) yielded 107 cases of NHNA in the world literature, mostly female patients with adolescent-onset disease. We report the first two cases of adolescent-onset NHNA from the Philippines. To our knowledge, these are also the first two cases of extensive bilateral NHNA reported in which the lesions have extended beyond the areolae affecting the surrounding periareolar skin, covering almost the entire breast. Medical treatment of NHNA has been commonly associated with treatment failure or recurrence after treatment cessation, requiring intermittent therapy. However, our two cases had successful outcomes with medical treatment using a combination topical steroid/salicylic acid ointment with > 2 years of follow-up.
自1923年首次描述乳晕乳头痣样角化过度症（NHNA）以来，记录在案的病例很少。最近在PubMed上进行的一次检索（2014年3月）在世界文献中发现了107例NHNA病例，大多数为青春期发病的女性患者。我们报告了菲律宾首例青春期发病的NHNA病例。据我们所知，这也是首次报告的两例广泛性双侧NHNA病例，其病变超出乳晕范围，累及乳晕周围皮肤，几乎覆盖整个乳房。NHNA的药物治疗通常与治疗失败或停药后复发相关，需要间歇性治疗。然而，我们的两例患者使用外用类固醇/水杨酸软膏联合治疗取得了成功，随访超过2年。
