产自阿尔及利亚东北部的独活属植物中的三萜皂苷。
Triterpenoid saponins from Scabiosa stellata collected in North-eastern Algeria.
机构信息
Université des frères Mentouri-Constantine, Département de chimie, Laboratoire d'Obtention des Substances Thérapeutiques (LOST), Campus Chaabet-Ersas, 25000, Constantine, Algeria; ICMR-UMR CNRS 7312, Groupe Isolement et Structure, Campus Sciences, Bât. 18, BP 1039, 51687, Reims, France.
ICMR-UMR CNRS 7312, Groupe Isolement et Structure, Campus Sciences, Bât. 18, BP 1039, 51687, Reims, France.
出版信息
Phytochemistry. 2018 Jun;150:40-49. doi: 10.1016/j.phytochem.2018.03.005. Epub 2018 Mar 13.
Eight undescribed triterpenoid saponins, scabiostellatosides A-H, together with three known compounds were isolated from the whole plant of Scabiosa stellata L. Their structures were established by spectroscopic analyses (1D, 2D-NMR and HRESIMS) and chemical methods. Scabiostellatosides A-H were evaluated for their cytotoxicity against human fibrosarcoma cell line (HT1080). Scabiostellatoside F, a heptasaccharide derivative of oleanolic acid, exhibited moderate cytotoxicity against HT1080 cell line with IC value of 12.0 μM.
从糙毛独活全草中分离得到了 8 个未被描述的三萜皂苷，分别命名为 scabiostellatoside A-H，同时还分离得到了 3 个已知化合物。通过波谱分析（1D、2D-NMR 和 HRESIMS）和化学方法确定了它们的结构。对这些化合物进行了人纤维肉瘤细胞系（HT1080）的细胞毒性评价。其中，齐墩果酸的七糖衍生物 scabiostellatoside F 对 HT1080 细胞系表现出中等的细胞毒性，IC 值为 12.0 μM。
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