微小RNA在虫媒病毒/载体相互作用中的作用。

Australian Infectious Disease Research Centre, School of Biological Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.

Viruses. 2014 Sep 23;6(9):3514-34. doi: 10.3390/v6093514.

The role of microRNAs (miRNAs) as small non-coding RNAs in regulation of gene expression has been recognized. They appear to be involved in regulation of a wide range of cellular pathways that affect several biological processes such as development, the immune system, survival, metabolism and host-pathogen interactions. Arthropod-borne viruses impose great economic and health risks around the world. Recent advances in miRNA biology have shed some light on the role of these small RNAs in vector-virus interactions. In this review, I will reflect on our current knowledge on the role of miRNAs in arbovirus-vector interactions and the potential avenues for their utilization in limiting virus replication and/or transmission.

微小RNA（miRNA）作为小型非编码RNA在基因表达调控中的作用已得到认可。它们似乎参与调控广泛的细胞通路，这些通路影响多种生物学过程，如发育、免疫系统、生存、代谢以及宿主与病原体的相互作用。节肢动物传播的病毒在全球范围内带来巨大的经济和健康风险。miRNA生物学的最新进展为这些小RNA在载体 - 病毒相互作用中的作用提供了一些线索。在这篇综述中，我将阐述我们目前对miRNA在虫媒病毒 - 载体相互作用中的作用的认识，以及利用它们限制病毒复制和/或传播的潜在途径。