Conda-Sheridan Martin, Lee Sungsoo S, Preslar Adam T, Stupp Samuel I
Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL 60611, USA.
Chem Commun (Camb). 2014 Nov 18;50(89):13757-60. doi: 10.1039/c4cc06340f.
Nanofibre forming peptide amphiphiles were conjugated to naproxen through an esterase-sensitive linker. The amount of naproxen released, in the presence of enzymes, was influenced by the linker conjugating the drug to the supramolecular assembly. In vitro studies showed the anti-inflammatory activity of the released drug was maintained.
纳米纤维形成肽两亲物通过酯酶敏感连接子与萘普生偶联。在酶存在的情况下，萘普生的释放量受将药物与超分子组装体偶联的连接子影响。体外研究表明，释放出的药物的抗炎活性得以保持。
