萘普生从超分子纳米纤维中的酯酶激活释放。
Esterase-activated release of naproxen from supramolecular nanofibres.
作者信息
Conda-Sheridan Martin, Lee Sungsoo S, Preslar Adam T, Stupp Samuel I
机构信息
Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL 60611, USA.
出版信息
Chem Commun (Camb). 2014 Nov 18;50(89):13757-60. doi: 10.1039/c4cc06340f.
Abstract
Nanofibre forming peptide amphiphiles were conjugated to naproxen through an esterase-sensitive linker. The amount of naproxen released, in the presence of enzymes, was influenced by the linker conjugating the drug to the supramolecular assembly. In vitro studies showed the anti-inflammatory activity of the released drug was maintained.
摘要
纳米纤维形成肽两亲物通过酯酶敏感连接子与萘普生偶联。在酶存在的情况下，萘普生的释放量受将药物与超分子组装体偶联的连接子影响。体外研究表明，释放出的药物的抗炎活性得以保持。
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Biomaterials. 2014 Oct;35(30):8678-86. doi: 10.1016/j.biomaterials.2014.06.054. Epub 2014 Jul 16.
2
Internal dynamics of a supramolecular nanofibre.超分子纳米纤维的内部动力学
Nat Mater. 2014 Aug;13(8):812-6. doi: 10.1038/nmat3979. Epub 2014 May 25.
3
Gel scaffolds of BMP-2-binding peptide amphiphile nanofibers for spinal arthrodesis.用于脊柱融合的BMP-2结合肽两亲性纳米纤维凝胶支架
Adv Healthc Mater. 2015 Jan 7;4(1):131-141. doi: 10.1002/adhm.201400129. Epub 2014 Apr 22.
4
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7
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J Am Chem Soc. 2013 Feb 27;135(8):2907-10. doi: 10.1021/ja3115983. Epub 2013 Feb 13.
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ACS Nano. 2012 Oct 23;6(10):9335-46. doi: 10.1021/nn302148p. Epub 2012 Aug 15.
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