Kan Hiromi, Yamagishi Sho-ichi, Ojima Ayako, Fukami Kei, Ueda Seiji, Takeuchi Masayoshi, Hyogo Hideyuki, Aikata Hiroshi, Chayama Kazuaki
Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan.
J Clin Lab Anal. 2015 Nov;29(6):480-4. doi: 10.1002/jcla.21797. Epub 2014 Sep 23.
The prevalence of non-B or non-C hepatocellular carcinoma (NBNC-HCC) has been increasing all over the world. Advanced glycation end products (AGE) play a role in the pathogenesis of alcoholic liver injury or nonalcoholic steatohepatitis (NASH).
We examined here whether serum levels of AGE were elevated in NBNC-HCC patients compared with NASH subjects without HCC and investigated which anthropometric and clinical variables were independent determinants of AGE.
Ninety NBNC-HCC, 56 NASH, and 27 control subjects underwent a complete history and physical examination, determination of blood chemistries, including AGE levels. Serum levels of AGE were significantly higher in NBNC-HCC patients compared with NASH and control subjects [9.1 ± 2.7, 5.2 ± 1.7, 3.5 ± 1.2 (U/ml), respectively, P < 0.05]. Univariate analysis showed that AGE levels were associated with male (P < 0.05), age (P < 0.01), aspartate aminotransferase (P < 0.05), γ-glutamyl transpeptidase (GGT) (P < 0.01), HDL-cholesterol (inversely, P < 0.01), fasting plasma glucose (P < 0.01), and HbA1c (P < 0.05). By the use of multiple stepwise regression analysis, age, GGT, and HDL-cholesterol (inversely) remained significant and were independently related to AGE levels (R(2) = 0.406).
The present results suggest that AGE might be involved in the pathogenesis of NBNC-HCC, thereby being a biomarker that could discriminate NBNC-HCC from NASH.
非B或非C型肝细胞癌（NBNC-HCC）在全球的患病率一直在上升。晚期糖基化终产物（AGE）在酒精性肝损伤或非酒精性脂肪性肝炎（NASH）的发病机制中起作用。
我们在此检查了与无HCC的NASH受试者相比，NBNC-HCC患者血清AGE水平是否升高，并研究了哪些人体测量和临床变量是AGE的独立决定因素。
90例NBNC-HCC患者、56例NASH患者和27例对照受试者接受了完整的病史和体格检查，测定了包括AGE水平在内的血液化学指标。与NASH和对照受试者相比，NBNC-HCC患者的血清AGE水平显著更高[分别为9.1±2.7、5.2±1.7、3.5±1.2（U/ml），P<0.05]。单因素分析显示，AGE水平与男性（P<0.05）、年龄（P<0.01）、天冬氨酸转氨酶（P<0.05）、γ-谷氨酰转肽酶（GGT）（P<0.01）、高密度脂蛋白胆固醇（呈负相关，P<0.01）、空腹血糖（P<0.01）和糖化血红蛋白（P<0.05）有关。通过多元逐步回归分析，年龄、GGT和高密度脂蛋白胆固醇（呈负相关）仍然显著，并且与AGE水平独立相关（R² = 0.406）。
目前的结果表明，AGE可能参与了NBNC-HCC的发病机制，从而成为一种可将NBNC-HCC与NASH区分开来的生物标志物。
