Bjorkman D J, Brigham E J, Peterson B J, Straight R C
Division of Gastroenterology, Utah Laser Institute, University of Utah School of Medicine, Salt Lake City 84132.
Lasers Surg Med. 1989;9(3):286-9. doi: 10.1002/lsm.1900090313.
Laser excitation of photodynamic agents localizing in colonic tumors may allow the early diagnosis and treatment of colon cancer. The efficacy of these agents requires a high ratio of tumor to background photosensitizer accumulation and fluorescence. To assess normal colonic background fluorescence and hematoporphyrin accumulation 31 rats were studied after an intravenous injection of Photofrin II (PF-II) at a dose of 5 mg/kg. An increase in mucosal fluorescence and porphyrin content was noted in the cecum 24 hours after injection. Cecal accumulation of PF-II may affect its efficacy in the localization and treatment of cecal tumors. Further investigation into the mechanism and clinical significance of this finding is needed.
对定位在结肠肿瘤中的光动力剂进行激光激发，可能有助于结肠癌的早期诊断和治疗。这些药剂的疗效需要肿瘤与背景光敏剂积累及荧光的高比例。为评估正常结肠的背景荧光和血卟啉积累情况，31只大鼠在静脉注射剂量为5mg/kg的二血卟啉醚（PF-II）后接受了研究。注射后24小时，盲肠的黏膜荧光和卟啉含量增加。PF-II在盲肠的积累可能会影响其在盲肠肿瘤定位和治疗中的疗效。需要对这一发现的机制和临床意义进行进一步研究。
