Thomas J P, Girotti A W
Photochem Photobiol. 1989 Mar;49(3):241-7. doi: 10.1111/j.1751-1097.1989.tb04102.x.
Rhabdomyosarcoma tumors in rats made hyperglycemic by multiple injections of glucose exhibited a transient decrease in pH and an increased ability to accumulate derivatives of hematoporphyrin (HPD). Photoradiation of tumors in glucose/HPD-treated animals produced a greater cell kill than in galactose/HPD-treated controls. A therapeutic benefit of glucose administration in conjunction with HPD-phototherapy is suggested.
通过多次注射葡萄糖使大鼠产生高血糖后，其横纹肌肉瘤肿瘤的pH值出现短暂下降，且积累血卟啉衍生物（HPD）的能力增强。与半乳糖/HPD处理的对照组相比，葡萄糖/HPD处理的动物肿瘤经光辐射后产生的细胞杀伤作用更大。这表明葡萄糖给药与HPD光疗联合具有治疗益处。
