Keverne E B, Martensz N D, Tuite B
Department of Anatomy, University of Cambridge, U.K.
Psychoneuroendocrinology. 1989;14(1-2):155-61. doi: 10.1016/0306-4530(89)90065-6.
Social relationships are integral to the behaviour of many mammalian species. Primates are unusual in that their social relationships are extensive within groups, which often contain many reproductively active males and females. Several hypotheses have been forwarded to explain the ultimate causation of primate sociality. While attention has focused on grooming as a proximate factor influencing social relationships, the neural basis of such behaviour has not been investigated in monkeys. This report presents changes in the brain's opioid system contingent on grooming in monkeys. Opiates themselves have a feedback interaction with grooming behaviour, as revealed from the administration of opiate agonists and antagonists. Opiate receptor blockade increases the motivation to be groomed, while morphine administration decreases it. These data support the view that brain opioids play an important role in mediating social attachment and may provide the neural basis on which primate sociality has evolved.
社会关系是许多哺乳动物物种行为不可或缺的一部分。灵长类动物与众不同之处在于，它们在群体内的社会关系广泛，群体中通常包含许多具有生殖活性的雄性和雌性。已经提出了几种假说来解释灵长类动物社会性的最终成因。虽然注意力集中在梳理毛发作为影响社会关系的一个近因因素上，但这种行为的神经基础在猴子身上尚未得到研究。本报告展示了猴子梳理毛发时大脑阿片系统的变化。从阿片类激动剂和拮抗剂的给药情况可以看出，阿片类药物本身与梳理毛发行为存在反馈相互作用。阿片受体阻断会增加被梳理毛发的动机，而注射吗啡则会降低这种动机。这些数据支持了这样一种观点，即大脑阿片类物质在介导社会依恋方面发挥着重要作用，并且可能为灵长类动物社会性的进化提供神经基础。
