Department of Prosthodontics, Warsaw Medical University, 59 Nowogrodzka St., Warsaw, 02-005, Poland,
Adv Exp Med Biol. 2015;839:25-30. doi: 10.1007/5584_2014_42.
Patients with chronic obstructive pulmonary disease (COPD) have the lower airways colonized with pathogenic bacteria in a stable period of the disease and during exacerbations. The etiology of bacterial exacerbations of COPD depends on the underlying disease, the frequency of exacerbations and antibiotic therapy. Microorganisms can be aspirated off the denture plaque biofilm into the lower respiratory tract and could reduce the patient's immunity and cause pneumonia. COPD patients, who are using acrylic dentures in oral cavity, are exposed to denture stomatitis and oral candidiasis. The aim of this study was to establish the composition of denture plaque biofilm and its impact on the oral mucosa in COPD patients. The study included patients in a stable phase of COPD using removable denture and the control group included healthy wearer's appliances. Examinations concerned the oral mucosal membrane and the hygienic condition of prosthetic restorations. Microbiological examinations were performed by taking a direct swab from the surface of acrylic dentures. Seventeen bacterial and fungal strains were isolated from denture plaque of COPD patients, which could be a reservoir of pathogens in the upper and lower airways. The results showed a greater frequency of prosthetic stomatitis complicated by mucosal infections among COPD patients compared to healthy subjects.
慢性阻塞性肺疾病（COPD）患者在疾病稳定期和加重期，下气道定植有致病性细菌。COPD 细菌加重的病因取决于基础疾病、加重的频率和抗生素治疗。微生物可以从义齿斑块生物膜中被吸入下呼吸道，从而降低患者的免疫力并导致肺炎。COPD 患者口腔中使用丙烯酸义齿，易患义齿性口炎和口腔念珠菌病。本研究旨在确定义齿斑块生物膜的组成及其对 COPD 患者口腔黏膜的影响。该研究包括使用可摘义齿的 COPD 稳定期患者和对照组的健康义齿佩戴者。检查包括口腔黏膜和义齿修复体的卫生状况。通过直接从丙烯酸义齿表面拭取，进行微生物学检查。从 COPD 患者的义齿斑块中分离出 17 种细菌和真菌菌株，它们可能是上、下呼吸道病原体的储库。结果表明，与健康受试者相比，COPD 患者的义齿性口炎伴黏膜感染更为频繁。
