Song Yuanchao, Hou Jian, Huang Xiji, Zhang Xiaomin, Tan Aijun, Rong Yi, Sun Huizhen, Zhou Yun, Cui Xiuqing, Yang Yuqing, Guo Yanjun, Zhang Zhihong, Luo Xin, Zhang Bing, Hou Fan, He Xiaosheng, Xie Jungang, Wu Tangchun, Chen Weihong, Yuan Jing
Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
BMC Public Health. 2014 Sep 24;14:994. doi: 10.1186/1471-2458-14-994.
Particulate air pollution has been recognized to be associated with a wide range of adverse health effects, including increased mortality, morbidity, exacerbation of respiratory conditions. However, earlier physiological or pathological changes or long-term bodies' reaction to air pollutants have not been studied in depth in China. The Wuhan-Zhuhai (WHZH) cohort study is designed to investigate the association between air pollutants exposure and physiological or pathological reactions on respiratory and cardiovascular system.
METHODS/DESIGN: The cohort is a community-based prospective study that includes 4812 individuals aged 18-80 years. The collections of data were conducted from April to May 2011 in Wuhan city and in May 2012 in Zhuhai city. At baseline, data on demographic and socioeconomic information, occupational history, family disease history, lifestyle, cooking mode, daily travel mode, physical activity and living condition have been collected by questionnaires. Participants underwent an extensive physical examination, including anthropometry, spirometry, electrocardiography, and measurements of blood pressure, heart rate, exhaled nitric oxide and carbon monoxide. Potential conditions in the lung, heart, liver, spleen, and skin were synchronously performed. In addition, samples of morning urine, fasting blood serum and plasma were collected during physical health examination. DNA were extracted and were stored at -80°C. Environment concentrations of particulate matter and chemicals were determined for 15 days in each of four seasons. Participants are followed for physiological or pathological changes or incidence of cardiopulmonary diseases every 3 years.
The results obtained in WHZH cohort study may increase a better understanding of the relationship between particulate air pollution and its components and possible health damages. And the potential mechanisms underlying the development of cardiopulmonary diseases has implications for the development of prevention and treatment strategies.
人们已经认识到，空气中的颗粒物污染与广泛的不良健康影响相关，包括死亡率增加、发病率上升、呼吸系统疾病加重。然而，中国尚未对早期生理或病理变化或身体对空气污染物的长期反应进行深入研究。武汉-珠海（WHZH）队列研究旨在调查空气污染物暴露与呼吸和心血管系统的生理或病理反应之间的关联。
方法/设计：该队列是一项基于社区的前瞻性研究，包括4812名年龄在18至80岁之间的个体。数据收集于2011年4月至5月在武汉市以及2012年5月在珠海市进行。在基线时，通过问卷调查收集了人口统计学和社会经济信息、职业史、家族病史、生活方式、烹饪方式、日常出行方式、身体活动和生活条件等数据。参与者接受了全面的身体检查，包括人体测量、肺活量测定、心电图检查，以及血压、心率、呼出一氧化氮和一氧化碳的测量。同时对肺、心脏、肝脏、脾脏和皮肤的潜在状况进行了检查。此外，在身体健康检查期间收集了晨尿、空腹血清和血浆样本。提取DNA并储存在-80°C。在四个季节的每个季节中，对颗粒物和化学物质的环境浓度进行了15天的测定。每3年对参与者进行一次生理或病理变化或心肺疾病发病率的随访。
WHZH队列研究获得的结果可能会增进对空气中颗粒物污染及其成分与可能的健康损害之间关系的更好理解。而心肺疾病发展的潜在机制对预防和治疗策略的制定具有重要意义。
