使用鸡胚绒毛尿囊膜试验研究半乳糖凝集素在体内血管生成过程中的作用。
Examination of the role of galectins during in vivo angiogenesis using the chick chorioallantoic membrane assay.
作者信息
Kleibeuker Esther A, Schulkens Iris A E, Castricum Kitty C M, Griffioen Arjan W, Thijssen Victor L J L
机构信息
Angiogenesis Laboratory Amsterdam, Department of Radiation Oncology, VU University medical center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
出版信息
Methods Mol Biol. 2015;1207:305-15. doi: 10.1007/978-1-4939-1396-1_20.
Angiogenesis is a complex multi-process involving various activities of endothelial cells. These activities are influenced in vivo by environmental conditions like interactions with other cell types and the microenvironment. Galectins play a role in several of these interactions and are therefore required for proper execution of in vivo angiogenesis. In this chapter we describe a method to study galectins and galectin inhibitors during physiologic and pathophysiologic angiogenesis in vivo using the chicken chorioallantoic membrane (CAM) assay.
血管生成是一个复杂的多过程，涉及内皮细胞的各种活动。这些活动在体内受到与其他细胞类型相互作用以及微环境等环境条件的影响。半乳糖凝集素在其中一些相互作用中发挥作用，因此对于体内血管生成的正常进行是必需的。在本章中，我们描述了一种利用鸡胚绒毛尿囊膜（CAM）试验在体内生理和病理生理血管生成过程中研究半乳糖凝集素和半乳糖凝集素抑制剂的方法。
Zotero 插件