Ariizumi Shun-ichi, Yamamoto Masakazu
Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Kawada 8-1, Shinjuku-ku, Tokyo, 162-0054, Japan,
Surg Today. 2015 Jun;45(6):682-7. doi: 10.1007/s00595-014-1031-0. Epub 2014 Sep 25.
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer. Cirrhosis and chronic viral hepatitis are known to be important risk factors for ICC, especially the mass-forming (MF) type of ICC at the periphery of the liver. Cholangiolocellular carcinoma (CoCC) is a rare type of primary liver cancer, which is thought to originate from hepatic progenitor or stem cells. CoCC often exhibits the similar MF type at the periphery of the liver, as ICC, and CoCC is also associated with cirrhosis or chronic viral hepatitis. Better survival rates after surgery have been reported for ICC patients with chronic viral hepatitis than for those without chronic viral hepatitis, although survival rates did not differ significantly in relation to cirrhosis. On the other hand, patients with CoCC had better surgical results than those with MF-type ICC. This review summarizes the clinical characteristics and surgical outcomes of ICC and CoCC associated with cirrhosis or chronic viral hepatitis.
肝内胆管癌（ICC）是第二常见的原发性肝癌。已知肝硬化和慢性病毒性肝炎是ICC的重要危险因素，尤其是肝脏周边的肿块形成（MF）型ICC。胆管细胞癌（CoCC）是一种罕见的原发性肝癌，被认为起源于肝祖细胞或干细胞。CoCC在肝脏周边通常表现出与ICC相似的MF型，并且CoCC也与肝硬化或慢性病毒性肝炎有关。据报道，患有慢性病毒性肝炎的ICC患者术后生存率高于未患慢性病毒性肝炎的患者，尽管肝硬化患者的生存率无显著差异。另一方面，CoCC患者的手术效果优于MF型ICC患者。本综述总结了与肝硬化或慢性病毒性肝炎相关的ICC和CoCC的临床特征及手术结果。
