Department of Radiology, Nihon University School of Medicine, 30-1, Ohyaguchi Kami-cho, Itabashi-ku, Tokyo, 173-8610, Japan.
Department of Radiology, Showa General Hospital, Koganei, Japan.
Eur Radiol. 2017 Nov;27(11):4461-4471. doi: 10.1007/s00330-017-4811-2. Epub 2017 Apr 24.
To review the gadoxetic acid disodium (EOB)-enhanced magnetic resonance (MR) imaging features of cholangiolocellular carcinoma (CoCC) of the liver and compare them with those of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC).
EOB-enhanced MR images of 19 patients with CoCC, 23 with ICC, and 51 with HCC were retrospectively evaluated qualitatively and quantitatively. Univariate and multivariate analyses were performed to determine the characteristic MR features of CoCC with histopathological-imaging correlation.
Multivariate logistic regression analysis showed that dot-/band-shaped internal enhancement during the arterial and portal phases (P < 0.001), and larger arterial ring enhancement ratio (CoCC, 0.13 ± 0.04; ICC, 0.074 ± 0.04; P = 0.013) were significantly independently associated with CoCC in contrast to ICC, whereas several MR features including progressive enhancement during the portal and late phases (P < 0.001), target appearance in the hepatocyte phase (P = 0.004), and vessel penetration (P = 0.013) were significantly more frequently associated with CoCC than HCC. The dot-/band-like internal enhancement (78.9% of CoCCs) histopathologically corresponded to the tumour cell nest with vascular proliferations and retained Glisson's sheath structure.
EOB-enhanced MR features of CoCC largely differ from those of HCC but are similar to those of ICC. However, the finding of thicker arterial ring enhancement with dot-/band-like internal enhancement could help differentiate CoCC from ICC.
• Gadoxetic acid-enhanced MR features of cholangiolocellular carcinoma (CoCC) resembled those of intrahepatic cholangiocarcinoma (ICC). • Gadoxetic acid-enhanced MR features of CoCC largely differed from those of hepatocellular carcinoma. • Dot-/band-like internal enhancement of CoCC may be helpful for differentiating from ICC. • Arterial ring enhancement of CoCC was larger than that of ICC.
回顾钆塞酸二钠（EOB）增强磁共振（MR）成像在肝内胆小管细胞癌（CoCC）中的表现，并与肝细胞癌（HCC）和肝内胆管细胞癌（ICC）进行比较。
回顾性分析 19 例 CoCC、23 例 ICC 和 51 例 HCC 的 EOB 增强 MR 图像，进行定性和定量分析。通过单变量和多变量分析，结合组织病理学和影像学进行相关性分析，确定 CoCC 的特征性 MR 表现。
多变量逻辑回归分析显示，动脉期和门静脉期的点状/条带状内部强化（P < 0.001）和较大的动脉环强化比值（CoCC，0.13 ± 0.04；ICC，0.074 ± 0.04；P = 0.013）与 ICC 相比，与 CoCC 显著相关，而一些 MR 特征，包括门静脉期和延迟期的渐进性强化（P < 0.001）、肝细胞期的靶征（P = 0.004）和血管穿透（P = 0.013）与 CoCC 相比，更常见于 CoCC 而不是 HCC。点状/条带状内部强化（78.9%的 CoCC）与具有血管增生和保留 Glisson 鞘结构的肿瘤细胞巢在组织病理学上相对应。
EOB 增强 MR 特征在很大程度上不同于 HCC，但与 ICC 相似。然而，发现较厚的动脉环强化与点状/条带状内部强化有助于将 CoCC 与 ICC 区分开来。
胆内胆小管细胞癌（CoCC）的钆塞酸二钠增强磁共振（MR）特征与肝内胆管细胞癌（ICC）相似。
CoCC 的 EOB 增强 MR 特征与肝细胞癌（HCC）有很大的不同。
CoCC 的点状/条带状内部强化可能有助于与 ICC 区分。
CoCC 的动脉环强化大于 ICC。
