Ibrahim Kinda, Donyai Parastou
University of Reading, UK.
University of Reading, UK
J Atten Disord. 2015 Jul;19(7):551-68. doi: 10.1177/1087054714548035. Epub 2014 Sep 24.
ADHD is managed by stimulants that are effective but can cause growth retardation. Prescribers should ideally monitor children and trial a "drug holiday" to enable catch-up growth. Our aim was to map the experience of drug holidays from ADHD medication in children and adolescents.
A comprehensive search of the literature identified 22 studies published during the period 1972 to 2013.
Drug holidays are prevalent in 25% to 70% of families and are more likely to be exercised during school holidays. They test whether medication is still needed and are also considered for managing medication side effects and drug tolerance. The impact of drug holidays was reported in terms of side effects and ADHD symptoms. There was evidence of a positive impact on child growth with longer breaks from medication, and shorter breaks could reduce insomnia and improve appetite.
Drug holidays from ADHD medication could be a useful tool with multiple purposes: assessment, management, prevention, and negotiation.
注意力缺陷多动障碍（ADHD）通过兴奋剂进行治疗，这些药物有效但可能导致生长发育迟缓。理想情况下，开处方者应监测儿童并尝试“药物假期”以实现追赶生长。我们的目的是梳理儿童和青少年ADHD药物治疗中“药物假期”的经验。
对文献进行全面检索，确定了1972年至2013年期间发表的22项研究。
“药物假期”在25%至70%的家庭中普遍存在，且更有可能在学校假期期间进行。他们会测试是否仍需要用药，同时也考虑用于管理药物副作用和药物耐受性。“药物假期”的影响是根据副作用和ADHD症状来报告的。有证据表明，用药间隔时间更长对儿童生长有积极影响，而较短的间隔时间可以减少失眠并改善食欲。
ADHD药物治疗中的“药物假期”可能是一种具有多种用途的有用工具：评估、管理、预防和协商。
