Henry R L, Hankin R G, Abramson R
University of Newcastle, Newcastle Mater Hospital, Waratah, New South Wales, Australia.
Aust Paediatr J. 1989 Apr;25(2):86-8. doi: 10.1111/j.1440-1754.1989.tb01422.x.
A double-blind crossover study was performed on 33 children with asthma to compare the effectiveness of nebulized solutions of preservative-containing and preservative-free ipratropium bromide. Both solutions produced bronchodilation. No significant differences were found between the two solutions at any time after nebulization in minimum and maximum changes from baseline value or in the areas under the lung function time curves. The presently formulated preservative-containing ipratropium bromide solution was not shown to be inferior to a preservative-free compound.
对33名哮喘儿童进行了一项双盲交叉研究，以比较含防腐剂和不含防腐剂的异丙托溴铵雾化溶液的有效性。两种溶液均产生支气管扩张作用。雾化后任何时间，两种溶液在相对于基线值的最小和最大变化或肺功能时间曲线下面积方面均未发现显著差异。目前配制的含防腐剂的异丙托溴铵溶液并未显示出比不含防腐剂的化合物差。
