Nacaroglu Hikmet Tekin, Celegen Mehmet, Ozek Gülcihan, Umac Ozgur, Karkıner Canan Sule Unsal, Yıldırım Hulya Tosun, Can Demet
Department of Pediatric Allergy, Dr Behcet Uz Children's Hospital, Izmir, Turkey. Head of Department: Demet Can Assoc. Prof., MD.
Department of Pediatric Hematology, Dr Behcet Uz Children's Hospital, Izmir, Turkey. Head of Department: Canan Vergin Assoc. Prof., MD.
Postepy Dermatol Alergol. 2014 Aug;31(4):269-71. doi: 10.5114/pdia.2014.40938. Epub 2014 Sep 8.
Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous rash characterized by the abrupt onset of a generalized pustular rash often accompanied by fever. There is a history of drug use in 90% of the cases. Here we have reported a 15-year-old male patient with sickle cell anemia who developed AGEP after the use of ceftriaxone. Our patient was hospitalized because of vaso-occlusive crisis and on the third day of ceftriaxone treatment, erythematous pustular lesions accompanied with fever were observed on the body and extremities. Resolution of symptoms followed discontinuation of ceftriaxone. Sensitivity to ceftriaxone was shown with a patch test. The AGEP was considered due to clinical and histopathological findings. This is the first pediatric case of AGEP due to ceftriaxone.
急性泛发性脓疱性皮病（AGEP）是一种罕见的皮肤疹，其特征为全身性脓疱疹突然发作，常伴有发热。90%的病例有用药史。在此，我们报告了一名15岁患镰状细胞贫血的男性患者，其在使用头孢曲松后发生了AGEP。我们的患者因血管闭塞性危机住院，在头孢曲松治疗的第三天，在身体和四肢观察到伴有发热的红斑性脓疱病变。停用头孢曲松后症状消退。斑贴试验显示对头孢曲松过敏。根据临床和组织病理学 findings，诊断为AGEP。这是首例因头孢曲松引起的儿童AGEP病例。 （注：原文中“findings”未翻译完整，可能是“发现”等意思，这里直接保留英文，你可根据实际情况补充完整准确的中文表述）
