J Cutan Med Surg. 2013 Nov-Dec;17(6):414-8. doi: 10.2310/7750.2013.12105.
Acute generalized exanthematous pustulosis (AGEP) is a rare drug eruption presenting with an acute, extensive formation of nonfollicular sterile pustules on an erythematous and edematous base. Typically, the rash is accompanied by fever and leukocytosis, with spontaneous resolution in < 15 days. The incidence of AGEP is estimated at one to five cases per million people per year. Only 18% of these are from nonantibiotics. Hydroxychloroquine (HCQ) is an antimalarial agent that is also used to treat various dermatologic and rheumatologic conditions.
We report the first observation in Canada of a patient with AGEP induced by HCQ.
AGEP was diagnosed in a 48-year-old female who had been taking HCQ for 2 weeks and then developed a diffuse erythematous and edematous pustular eruption. Clinical and pathologic findings were consistent with a diagnosis of AGEP. The patient was treated with steroids and supportive measures. The rash resolved after 18 days and a complicated course in hospital.
AGEP is a rare drug eruption, usually to antibiotics. We report the first case in Canada of AGEP as an adverse reaction to HCQ. Clinicians should keep in mind the possibility of this severe skin eruption.
急性泛发性发疹性脓疱病（AGEP）是一种罕见的药物性发疹，表现为在红斑和水肿的基础上迅速出现非滤泡性无菌脓疱。通常，皮疹伴有发热和白细胞增多，15 天内自发消退。AGEP 的发病率估计为每年每百万人中有 1 至 5 例，其中只有 18%是非抗生素引起的。羟氯喹（HCQ）是一种抗疟药，也用于治疗各种皮肤和风湿疾病。
我们报告了加拿大首例由 HCQ 引起的 AGEP 病例。
一名 48 岁女性在服用 HCQ 2 周后出现弥漫性红斑和水肿性脓疱性皮疹，诊断为 AGEP。临床和病理发现与 AGEP 一致。患者接受了类固醇和支持性治疗。皮疹在 18 天后消退，在医院经历了复杂的病程。
AGEP 是一种罕见的药物性发疹，通常与抗生素有关。我们报告了加拿大首例由 HCQ 引起的 AGEP 病例。临床医生应注意这种严重皮肤发疹的可能性。
